1ic8_B : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT (HEPATOCYTE NUCLEAR FACTOR 1-ALPHA)
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=0.260)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
sequence family	Hepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain;
multimeric complexes	1ic8_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_B interface=56,57,58,59,61,62,68,69,98,160,161,164,165,168, ilkelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgTPmktqkraalytwyvrkqrevaqqfthrnRfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfANrrKeeafr
interface signature	NQSHSQTPRYNANK

Estimated binding specificities ?

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# IC=10.241 IC/col=0.788 n_of_columns=13

specificity:

A |   0   0   3  13  62  24  24   3  92   0   3  96  96
C |   0   0  66  12  13  24  24   6   1   0   9   0   0
G |  96  96   1  62   8  24  24  11   0   0  18   0   0
T |   0   0  26   9  13  24  24  76   3  96  66   0   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: HEPATOCYTE 1A
TCAGTAAATA	PubMed	1ic8_AB(6.51e-03)
AAATAATGC	PubMed	1ic8_AB(6.53e-04)

Dendrogram of similar interfaces ?

matrix format

  
  NTQASAHTSTQT--TTPGRTYCNAATNAKG--   L          +-------------------1ic8_B    
                                         +------2 
  ----------------------IA--NA----       !      !                  +4qtr_D    
                                       --3      +------------------1 
  ------------------RT--ITQCNAACRG   L   !                         +6a8r_A    
                                         ! 
  --QASTCT--SARTET----------------   L   +--------------------------5j2y_A

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updated Tue Dec 19 05:43:24 2023