interface graph thumbnail
legend  pdf

structure nameGLUCOCORTICOID RECEPTOR MUTANT/DNA COMPLEX
(GLUCOCORTICOID RECEPTOR)
referenceGewirth et al. Nat.Struct.Biol. 2 386 1995
sourceRattus norvegicus
experimentX-ray (resolution=1.90, R-factor=?)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1lat_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKAR

Estimated binding specificities ?

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# IC=5.868 IC/col=0.978 n_of_columns=6 specificity:   
A |   0   0   0  13   0  13
C |   0   0   0  13  96  54
G |   0  96   0  27   0   0
T |  96   0  96  43   0  29
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: GLUCOCORTICOID RECEPTOR
TGTTCTPubMed1lat_A(1.42e-06), 1lat_AB(8.15e-05)
GGTACANNNTGTTCTPubMed1lat_A(3.45e-04), 1lat_AB(6.68e-03)
TGTTCCPubMed1lat_A(7.45e-11), 1lat_AB(4.63e-07)
GCTGTTCTGCPubMed1lat_A(9.78e-05)
TGTTCANNNTGTTCTPubMed1lat_A(4.86e-04), 1lat_AB(6.68e-03)
AGAACANNNTGTTCTPubMed1lat_A(4.86e-04), 1lat_AB(6.68e-03)
GCAGAACAGCPubMed1lat_A(9.78e-05)
AGAACAPubMed1lat_A(1.42e-06), 1lat_AB(8.15e-05)

Dendrogram of similar interfaces ?

matrix format
  
  --ECKGAG--RG   L   +-----------------------------4ond_A    
                     ! 
  CAECKG--KGRG   L   !                         +---1cit_A    
                   --5           +-------------2 
  --EAKG--KTRG   L   !   +-------3             +---4umm_A    
                     !   !       ! 
  ----KGVT--RG   L   +---4       +-----------------2c7a_B    
                         ! 
  --ECKGAGKGRG   L       !                        +1hcq_E    
                         +------------------------1 
  --ECKGAGKTRG   L                                +4aa6_B

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updated Sat Jan 10 04:46:04 2026