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structure nameDNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B
(PROTEIN ORPHAN NUCLEAR RECEPTOR NGFI-B)
referenceSigler et al. Nat.Struct.Biol. 6 471 1999
sourceRattus norvegicus
experimentX-ray (resolution=2.70, R-factor=?)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes6l6l_AB 6l6q_AB 6lc1_AD
reference complex6l6q_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureCEKKRRR

Estimated binding specificities ?

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# IC=7.965 IC/col=0.885 n_of_columns=9 specificity:   
A |  96  67  24  96   0   0  11  11  96
C |   0   9  24   0   0   0   9  67   0
G |   0  11  24   0  96  96   9   9   0
T |   0   9  24   0   0   0  67   9   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: NGFI-B
AGGTCAPubMed1cit_A(1.19e-08)
AAAGGTCAPubMed1cit_A(2.06e-09)
CAAGGTCAPubMed1cit_A(4.87e-06)
CCAAGGTCAPubMed1cit_A(2.40e-05)
NNAGGTCAPubMed1cit_A(4.87e-06)

Dendrogram of similar interfaces ?

matrix format
  
  --CA--EC--KG--KGRG----RT--RA--   L                   +6l6q_B    
                                              +-------14  
  ------EA--KG--RTRG------------   L          !        +1kb2_B    
                                       +-----25  
  ST----EC--KG--KGRG------------   L   !      !         +6fbq_A    
                                       !      +---------3 
  ------EC--KG--KGRG------------   L   !                +3e00_A    
                                       !  
  ------EC--KG--RGRG----KA------   L   !                +2nll_B    
                                       !            +--11  
  ------EA--KG--RTRTRT----------       !            !   ! +4umm_E    
                                       !            !   +-1 
  ------EA--KG--RTRTRT----------       !        +--19     +2han_B    
                                       !        !   !  
  ------EC--KG--KGRG------------   L -27        !   !   +1r0n_A    
                                       !        !   +---2 
  ------DA--KG--RGRG------------   L   !   +---23       +4iqr_B    
                                       !   !    !  
  ----HGECAGKGAAKGRT------RT--RC   L   !   !    !       +1lo1_A    
                                       !   !    !  +---15  
  ------EC--KG--KGRA--RT--------   L   !   !    !  !    +5l0m_A    
                                       !   !    +-21  
  ------EC--KG--KGRG------------   L   !   !       !     +1ynw_B    
                                       !   !       +-----5 
  ------EC--KG--RGRG------------   L   !   !             +5uan_B    
                                       +--26  
  ------EC--KG--KGRG--RC--------   L       !       +------2ff0_A    
                                           !       !  
  ------DG--KG--RTRG------------   L       !    +-22      +3cbb_A    
                                           !    !  !   +-12  
  ----HC----KGVT--RG------------           !    !  +--18  +3g9m_B    
                                           !    !      !  
  ------EC--KG--KTRG------------   L       !    !      +--2nll_A    
                                           !    !  
  ----HAEC--KG--RGRG------------   L       !    !         +1a6y_A    
                                           +---24       +-6 
  ----------KGVT--RG------------   L            !  +---16 +1glu_A    
                                                !  !    !  
  ----------KGVT--RG------------   L            !  !    +5cbz_E    
                                                !  !  
  ----------KGVT--RG------------   L            !  !         +2c7a_B    
                                                +-20      +-10  
  ----------KAVA--RA------------   L               !      !  ! +5e69_A    
                                                   !   +-13  +-4 
  ----------KGVG--RG------------   L               !   !  !    +5cbx_B    
                                                   !   !  !  
  ------EC--KG--RGRG------------   L               !   !  +3dzy_D    
                                                   +--17  
  ------ET--KGAT--RG------------   L                   !   +1lat_A    
                                                       ! +-8 
  ------EC--KG--KGRG------------   L                   ! ! +4nqa_H    
                                                       +-9 
  ----------KGVT--RG------------                         ! +5emc_A    
                                                         +-7 
  ----------KAVG--RG------------                           +5va7_A    
                                     

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updated Thu Sep 12 14:35:02 2024