interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF THE PROGESTERONE RECEPTOR-DNA COMPLEX
(PROGESTERONE RECEPTOR)
referenceChurchill et al. Mol.Endocrinol. 20 3042 2006
sourceHOMO SAPIENS
experimentX-ray (resolution=2.50, R-factor=0.203)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes2c7a_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVRR

Estimated binding specificities ?

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# IC=4.960 IC/col=0.709 n_of_columns=7 specificity:   
A |   0   0   7  24   9   7   7
C |   0   0   9  24  73   7   9
G |   0  96   7  24   7   7  73
T |  96   0  73  24   7  75   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ECKA--RGRG--   L   +-----------------------------4nqa_I    
                     !  
  EAKG--RTRTRT       !                         +---4umm_E    
                     !                 +-------7 
  --KGVT--RG--       !                 !       !  +1r4i_A    
                     !                 !       +--3 
  ECKG--KGRG--   L   !              +-10          +2ff0_A    
                     !              !  !  
  EAKG--KTRG--   L -13              !  !           +2han_A    
                     !              !  +-----------1 
  ECKG--KGRG--       !           +-11              +3dzy_A    
                     !           !  !  
  --KGVT--RG--   L   !           !  !               +5cbz_E    
                     !           !  !             +-5 
  DGKG--RTRG--   L   !           !  +-------------6 +3cbb_A    
                     !           !                ! 
  ECKG--RGRG--   L   +----------12                +3dzy_D    
                                 !  
  ECKG--RGRG--   L               !           +-----2nll_B    
                                 !     +-----8 
  ECKG--KTRG--   L               !     !     +-----2nll_A    
                                 +-----9 
  ECKG--KGRG--   L                     !            +1ynw_B    
                                       !          +-2 
  ECKG--RGRG--   L                     +----------4 +5uan_B    
                                                  ! 
  ETKGAT--RG--   L                                +1lat_A    
                   

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updated Thu Dec 22 18:08:56 2022