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structure nameTHE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS
(PROTEIN ESTROGEN RECEPTOR)
referenceSchwabe et al.
sourceHomo sapiens
experimentX-ray (resolution=2.40, R-factor=0.204)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes1hcq_AB 1hcq_EF 4aa6_AB 4aa6_EF
redundant complexes4aa6_E
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKAKR

Estimated binding specificities ?

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# IC=4.319 IC/col=0.864 n_of_columns=5 specificity:   
A |  15   0  54   0   0
C |  27   0  16  96  96
G |  13  96  13   0   0
T |  41   0  13   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ESTROGEN RECEPTOR
GGTCANNNTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(2.73e-12), 1hcq_EF(1.44e-12), ... (total=6)
GGTCAPubMed1hcq_E(8.51e-08), 1hcq_AB(1.84e-05), 1hcq_EF(1.71e-05), ... (total=6)
AGGTCAPubMed1hcq_E(3.71e-07), 1hcq_AB(2.17e-04), 1hcq_EF(2.05e-04), ... (total=6)
TGACCPubMed1hcq_E(8.51e-08), 1hcq_AB(1.84e-05), 1hcq_EF(1.71e-05), ... (total=6)
AGGTCANNNTGACCTPubMed1hcq_E(7.26e-05), 1hcq_AB(5.35e-11), 1hcq_EF(2.98e-11), ... (total=6)
AGGTCACAGPubMed1hcq_E(9.50e-06), 4aa6_A(3.63e-06)
GGTCAGAGTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(2.73e-12), 1hcq_EF(1.44e-12), ... (total=6)
GGTCANNNCGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(8.09e-08), 1hcq_EF(2.82e-08), ... (total=6)
GGTCAACATAACCPubMed1hcq_E(4.26e-05), 1hcq_AB(5.74e-08), 1hcq_EF(3.48e-08), ... (total=6)
GGTCAAGGCGATCPubMed1hcq_E(4.26e-05), 1hcq_AB(1.33e-04), 1hcq_EF(6.19e-05), ... (total=6)
GCTCGCGGTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(1.33e-04), 1hcq_EF(6.19e-05), ... (total=6)
ATGTCANNNTGACATPubMed1hcq_AB(1.79e-05), 1hcq_EF(1.21e-05), 4aa6_AB(1.24e-05), ... (total=5)
GGTCACTGTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(2.73e-12), 1hcq_EF(1.44e-12), ... (total=6)
CAGGTCAGAGTGACCTGPubMed1hcq_E(8.77e-05), 1hcq_AB(2.54e-10), 1hcq_EF(1.45e-10), ... (total=6)
GGTCAGTTTGACGPubMed1hcq_E(4.26e-05), 1hcq_AB(6.01e-09), 1hcq_EF(3.52e-09), ... (total=6)
GGTCACCATGCCCPubMed1hcq_E(4.26e-05), 1hcq_AB(4.02e-09), 1hcq_EF(3.48e-08), ... (total=6)
GGTCANNNCAGCCPubMed1hcq_E(4.26e-05), 1hcq_EF(1.23e-02), 4aa6_A(1.72e-05)
GGGCAAAGTGACTPubMed1hcq_AB(2.39e-06), 1hcq_EF(1.34e-05), 4aa6_AB(1.13e-05), ... (total=5)
GGTCTNNNAGACCPubMed1hcq_E(8.54e-03), 1hcq_AB(1.69e-04), 1hcq_EF(8.32e-05), ... (total=6)
TGACCTTAPubMed1hcq_E(4.43e-06), 1hcq_AB(8.58e-03), 1hcq_EF(8.28e-03), ... (total=6)
GGGTCANNNTGACCTPubMed1hcq_E(7.26e-05), 1hcq_AB(5.35e-11), 1hcq_EF(2.98e-11), ... (total=6)
GGTCAGCGTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(2.73e-12), 1hcq_EF(1.44e-12), ... (total=6)
GGGTCAACGTGACCTPubMed1hcq_E(7.26e-05), 1hcq_AB(5.35e-11), 1hcq_EF(2.98e-11), ... (total=6)
AGGACATGACCTPubMed1hcq_E(3.42e-05), 4aa6_A(1.38e-05)
CATAACCTTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(1.78e-03), 1hcq_EF(1.33e-03), ... (total=6)
TNAAGGTCAPubMed1hcq_E(9.50e-06), 4aa6_A(3.63e-06)
GGTGACCTTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(5.74e-08), 1hcq_EF(3.48e-08), ... (total=6)
AAGTCAAAGTGACCAPubMed1hcq_E(7.26e-05), 1hcq_AB(5.95e-08), 1hcq_EF(3.66e-08), ... (total=6)
GACCGGTCAGCGGACTCACPubMed1hcq_E(1.17e-04), 4aa6_A(4.82e-05)
TGACCTPubMed1hcq_E(3.71e-07), 1hcq_AB(2.17e-04), 1hcq_EF(2.05e-04), ... (total=6)
TGGTCAPubMed1hcq_E(3.71e-07), 1hcq_AB(2.17e-04), 1hcq_EF(2.05e-04), ... (total=6)
AGGTCAGAACACCCTPubMed1hcq_E(7.26e-05), 4aa6_A(2.99e-05)
CCAGAACACAGTGACCTGGPubMed1hcq_E(1.17e-04), 1hcq_AB(1.21e-03), 1hcq_EF(8.99e-04), ... (total=6)
GGGCANNNTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(4.02e-09), 1hcq_EF(3.48e-08), ... (total=6)
CCAGGTCACAGTGACCTGGPubMed1hcq_E(1.17e-04), 1hcq_AB(3.86e-10), 1hcq_EF(2.20e-10), ... (total=6)
GCAGANNNTGACCPubMed1hcq_E(4.26e-05), 4aa6_A(1.72e-05)
GTCTCACAGGTCAPubMed1hcq_E(4.26e-05), 4aa6_A(1.72e-05)
GGGTCAACGTGACGTPubMed1hcq_E(7.26e-05), 1hcq_AB(5.95e-08), 1hcq_EF(3.66e-08), ... (total=6)
GGTCACCACAGCCPubMed1hcq_E(4.26e-05), 1hcq_EF(1.23e-02), 4aa6_A(1.72e-05)
GGTCACAGTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(2.73e-12), 1hcq_EF(1.44e-12), ... (total=6)
TGTCAATCTGACCPubMed1hcq_E(4.26e-05), 1hcq_AB(6.01e-09), 1hcq_EF(3.52e-09), ... (total=6)
sitesourcematches (E-value)

Dendrogram of similar interfaces ?

matrix format
  
  EAKG--RTRTRT                              +--4umm_E    
                             +--------------6 
  ECKA--RGRG--   L   +------11              +--4nqa_I    
                     !       !  
  ECKG--KGRG--       !       +-----------------3dzy_A    
                     !  
  ECKG--RGRG--   L   !                      +--2nll_B    
                     !            +---------7 
  DGKG--RTRG--   L   !            !         +--3cbb_A    
                     !            ! 
  --KGVT--RG--     -13            !            +1r4i_A    
                     !       +----9          +-1 
  --KGVT--RG--   L   !       !    !      +---5 +5cbz_E    
                     !       !    !      !   ! 
  ECKG--RGRG--   L   !       !    !      !   +-3dzy_D    
                     !       !    +------8 
  ETKGAT--RG--   L   !       !           !       +1lat_A    
                     +------12           !     +-2 
  EAKG--KTRG--   L           !           +-----3 +2han_A    
                             !                 ! 
  ECKG--KGRG--   L           !                 +2ff0_A    
                             !  
  ECKG--KGRG--   L           !                   +1ynw_B    
                             !  +----------------4 
  ECKG--RGRG--   L           +-10                +5uan_B    
                                !  
  ECKG--KTRG--   L              +----------------2nll_A

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updated Sun Aug 3 05:35:04 2025