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structure nameCO-CRYSTAL STRUCTURE OF HUMAN YY1 ZINC FINGER DOMAIN BOUND TO THE ADENO-ASSOCIATED VIRUS P5 INITIATOR ELEMENT
(PROTEIN YY1 ZINC FINGER DOMAIN)
referenceHoubaviy et al. Proc.Natl.Acad.Sci.USA 93 13577 1996
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=0.212)
structural superfamilyC2H2 and C2HC zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKESKRLFNQTN

Estimated binding specificities ?

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# IC=12.322 IC/col=1.027 n_of_columns=12 specificity:   
A |   8  87  96  96  96   0   0   0  21   0  74  74
C |  59   8   0   0   0   0   0   0   4   0   8  14
G |   8   0   0   0   0   0  96  96   8  96  10   4
T |  21   1   0   0   0  96   0   0  63   0   4   4
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: YY1
GCCATTTTPubMed1ubd_C(2.23e-08)
AACTTCAAAATGGCTCCPubMed1ubd_C(1.10e-06)
GACATNTTPubMed1ubd_C(4.56e-03)
CCATNTTPubMed1ubd_C(2.45e-06)

Dendrogram of similar interfaces ?

matrix format
  
  --------KT--EC--SCKGRGLT--FCNA------QA--TTNA------   L                           +1ubd_C    
                                                                  +----------------1 
  KT--STHT----RG--DAQARGRGSTDCHG--TT--RG--DAEG--RG--   L     +----4                +6b0o_A    
                                                             !    ! 
  ------KGRG----TCYCKARGQA----TC------RA--SCDC--VT--         !    +-----------------5yeg_A    
                                                           +-5 
  ------------QA--TCNA--QAHTTT----QA--TTLAHGTCDTRG--   L   ! !                     +1g2d_F    
                                                           ! !      +--------------2 
  ----------NGKT----KG------HTHG--RGTGTT--ACNA--KGRG   L --6 +------3              +1tf3_A    
                                                           !        ! 
  RGSTDAHARG--RGSTDCHGTTRG--DAEG--RG----------------   L   !        +---------------5kl3_A    
                                                           ! 
  ----------RGST--YGYC--QC--TGSTRGYT----------------       +------------------------4is1_C    
                                                         

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updated Fri Sep 13 16:05:47 2024