1zlk_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS HYPOXIC RESPONSE REGULATOR DOSR C-TERMINAL DOMAIN-DNA COMPLEX (Dormancy Survival Regulator)
reference	Wisedchaisri et al. J.Mol.Biol. 354 630 2005
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=3.10, R-factor=0.272)
structural superfamily	C-terminal effector domain of the bipartite response regulators;
sequence family	Bacterial regulatory proteins, luxR family;
multimeric complexes	1zlk_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1zlk_A interface=35,36,38,39,40,42, dplsgltdqertllgllsegltnkqiadrmflaeKTvKNYvSrllaklgmerrtqaavfatelkr
interface signature	KTKNYS

Estimated binding specificities ?

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# IC=7.099 IC/col=1.014 n_of_columns=7

specificity:

A |  54   0   0   0  96   0  13
C |  13   0   0   0   0  96  16
G |  16  96  96  96   0   0  13
T |  13   0   0   0   0   0  54

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Dendrogram of similar interfaces ?

matrix format

  
  ----------------YG----           +-----------------------------3eyi_B    
                                 +-1 
  --SG--PTPGTT----------   L   +-2 +-----------------------------7d98_Q    
                               ! ! 
  TT----KATTQTTG--LTRTKA   L --3 +-----------------------------2p7c_B    
                               ! 
  --DCLT--AG--TTRG--RG--   L   +-----------------------------5h3r_A

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updated Sun Aug 3 06:05:46 2025