8cef_H : 3D-footprint complex

structure name	ASYMMETRIC DIMERIZATION IN A TRANSCRIPTION FACTOR SUPERFAMILY IS PROMOTED BY ALLOSTERIC INTERACTIONS WITH DNA (Nuclear receptor DNA binding domain)
reference	Billas et al. 'Nucleic 51 8864 2023
source	Mus musculus
experiment	X-ray (resolution=2.49, R-factor=0.216)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains;
multimeric complexes	8cef_CDJ 8cef_GHK
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cef_H interface=23,26,27,30,31,81,84, pkrlclvcgdvasgyhygvascEacKAffKRtiqgsieyscpasneceitkrrrkacqacrftkclrvgmlkegvrldrvRggRqky
interface signature	EKAKRRR

Estimated binding specificities ?

contact

# IC=3.044 IC/col=0.122 n_of_columns=25

specificity:

A |  24  25  10  14  24  69   3   9  19  13  63  24  24  24  24  24  24  24  24  24  24  24  24  24  24
C |  24  22  13  52  24   9   3   9  20  56  10  24  24  24  24  24  24  24  24  24  24  24  24  24  24
G |  24  27  10  16  24   9  85  69  19  14  10  24  24  24  24  24  24  24  24  24  24  24  24  24  24
T |  24  22  63  14  24   9   5   9  38  13  13  24  24  24  24  24  24  24  24  24  24  24  24  24  24

scan!

Dendrogram of similar interfaces ?

matrix format

  
  CAECKG--KGRG----RTRA   L   +-----------------------------6l6q_B    
                             ! 
  CAECKG--KGRG----RTRT   L --4       +---------------------7wnh_D    
                             ! +-----2 
  ----KGVG--RG--------   L   ! !     +---------------------5cbx_B    
                             +-3 
  --EC----RGRGRT------         !                          +8hbm_B    
                               +--------------------------1 
  --DAKG--RGRG--RT----   L                                +4iqr_B

home
updated Wed Dec 20 01:50:49 2023