8cef_H : 3D-footprint complex

structure name	ASYMMETRIC DIMERIZATION IN A TRANSCRIPTION FACTOR SUPERFAMILY IS PROMOTED BY ALLOSTERIC INTERACTIONS WITH DNA (Nuclear receptor DNA binding domain)
reference	Billas et al. 'Nucleic 51 8864 2023
source	Mus musculus
experiment	X-ray (resolution=2.49, R-factor=0.216)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains;
multimeric complexes	8cef_CDJ 8cef_GHK
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8cef_H interface=23,26,27,30,31,81,84, pkrlclvcgdvasgyhygvascEacKAffKRtiqgsieyscpasneceitkrrrkacqacrftkclrvgmlkegvrldrvRggRqky
interface signature	EKAKRRR

Estimated binding specificities ?

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# IC=3.010 IC/col=0.334 n_of_columns=9

specificity:

A |  10  13  39   9   3   9  24  14  63
C |  13  13  19  67  85  11  24  14  10
G |  10  57  19   9   5   9  24  54  10
T |  63  13  19  11   3  67  24  14  13

scan!

Dendrogram of similar interfaces ?

matrix format

  
  CAECKG--KGRG----RTRA   L   +-----------------------------6l6q_B    
                             ! 
  CAECKG--KGRG----RTRT   L --4       +---------------------7wnh_D    
                             ! +-----2 
  ----KGVG--RG--------   L   ! !     +---------------------5cbx_B    
                             +-3 
  --EC----RGRGRT------         !                          +8hbm_B    
                               +--------------------------1 
  --DAKG--RGRG--RT----   L                                +4iqr_B

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updated Wed Dec 18 16:27:18 2024