2han_A : 3D-footprint complex

structure name	STRUCTURAL BASIS OF HETERODIMERIC ECDYSTEROID RECEPTOR INTERACTION WITH NATURAL RESPONSE ELEMENT HSP27 GENE PROMOTER (PROTEIN ULTRASPIRACLE)
reference	Kolodziejczyk et al. 'Nucleic 35 2705 2007
source	DROSOPHILA MELANOGASTER
experiment	X-ray (resolution=1.95, R-factor=0.182)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains;
multimeric complexes	1r0o_AB 2han_AB
redundant complexes	1r0o
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2han_A interface=22,25,29,30,78, khlcsicgdrasgkhygvyscEgcKgffKRtvrkdltyacrenrnciidkrqrnrcqycryqkcltcgmkreavqeeR
interface signature	EKKRR

Estimated binding specificities ?

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# IC=5.849 IC/col=0.975 n_of_columns=6

specificity:

A |  13   0   0   0   0  57
C |  13   0   0   0  96  13
G |  57  96   0   0   0  13
T |  13   0  96  96   0  13

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ECDYSTEROID RECEPTOR
AGGTCA	PubMed	2han_A(6.84e-03), 1r0o_AB(6.75e-05)
GGTTCAATGCACT	PubMed	2han_A(1.21e-07), 1r0o_AB(5.41e-03), 2han_AB(2.75e-13), ... (total=4)

Dendrogram of similar interfaces ?

matrix format

  
  --EAKG--KTRG--   L                            +4umm_A    
                            +-------------------1 
  ----KGVG--RG--   L        !                   +4tnt_B    
                       +----6 
  --ECKGAG--KTRG   L   !    !    +--------------4aa6_B    
                       !    +----4 
  ----KGVT--RG--   L   !         !              +5emc_A    
                     --7         +--------------2 
  --ECKGAGKGRG--   L   !                        +1hcq_E    
                       ! 
  CAECKG--KGRG--   L   !                   +----1cit_A    
                       !      +------------3 
  ----KGVT--RG--   L   +------5            +----2c7a_B    
                              ! 
  --ECKGAG--RG--   L          +-----------------4ond_A

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updated Mon Jun 29 15:09:07 2026