2c9l_Z : 3D-footprint complex

structure name	STRUCTURE OF THE EPSTEIN-BARR VIRUS ZEBRA PROTEIN (BZLF1 TRANS-ACTIVATOR PROTEIN)
reference	Artero et al. Mol.Cell 21 565 2006
source	HUMAN HERPESVIRUS 4
experiment	X-ray (resolution=2.25, R-factor=0.232)
structural superfamily	Leucine zipper domain;
sequence family	bZIP transcription factor;
multimeric complexes	2c9l_YZ 2c9n_YZ 5szx_AB 7nx5_AB
redundant complexes	2c9n_Y 5szx_B 7nx5_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2c9l_Z interface=8,11,12,15,16, leikrykNrvAArkSRakfkqllqhyrevaaakssendrlrlllkqmcpsldvdsiiprtpd
interface signature	NAASR

Estimated binding specificities ?

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# IC=4.434 IC/col=0.887 n_of_columns=5

specificity:

A |  54   0   0  13  96
C |  13   0   0  54   0
G |  13  96   0  13   0
T |  16   0  96  16   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ZEBRA
TGAGCCA	PubMed	2c9l_Z(6.10e-03), 2c9l_YZ(4.25e-07), 2c9n_YZ(4.09e-07), ... (total=5)
TGACATCA	PubMed	2c9l_Z(1.77e-03)
TGAGTCA	PubMed	2c9l_Z(7.17e-07), 2c9l_YZ(1.11e-12), 2c9n_YZ(1.05e-12), ... (total=5)
TGAGCAA	PubMed	2c9l_YZ(1.66e-03), 2c9n_YZ(2.29e-03), 5szx_AB(1.05e-02), ... (total=4)

Dendrogram of similar interfaces ?

matrix format

  
  ----NC----ATAT----STRG--   L                     +-----2c9l_Z    
                                       +-----------1 
  ------NCRT--ATAT----STRG         +---2           +-----1t2k_D    
                                   !   ! 
  ----NC----AAAT------RT--   L   +-3   +-----------------1a02_F    
                                 ! ! 
  NT----ATAT----STRG------   L --4 +---------------------1dh3_C    
                                 ! 
  --NC----AT------CTRA----       +-----------------------1s9k_E

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updated Tue Dec 17 22:39:37 2024