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structure nameTHE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION
(PROTEIN TRAMTRACK DNA-BINDING DOMAIN)
referenceSchwabe et al.
sourceDrosophila melanogaster
experimentX-ray (resolution=2.80, R-factor=0.193)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHISNCRRDN

Estimated binding specificities ?

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# IC=6.585 IC/col=0.823 n_of_columns=8 specificity:   
A |   9   9  63   0   0   0   0  12
C |  10  11   5   1  96  96   1  23
G |  10  11  23   0   0   0   0  22
T |  67  65   5  95   0   0  95  39
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --QA----TC----RA--SCDC--VT--                 +-----------------------------5yeg_A    
                                             +-1 
  ------HTHGRGTGTT--ACNA--KGRG   L         +-2 +-----------------------------1tf3_A    
                                           ! ! 
  --EC--SCKGRG--LT--FCNA------   L       +-3 +-----------------------------1ubd_C    
                                         ! ! 
  --RGSTDCHGTT--RG--DAEG--RG--   L     +-4 +-----------------------------6b0o_A    
                                       ! ! 
  --QAHTTT--QA--TTLAHGTCDTRG--   L   +-5 +-----------------------------1g2d_F    
                                     ! ! 
  RGST--YGYC----QC--TGSTRGYT--     --6 +-----------------------------4is1_C    
                                     ! 
  --RGSTDCHGTT--RG--DAEG--RG--   L   +-----------------------------5kl3_A    
                                   

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updated Fri Sep 13 16:14:50 2024