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structure nameTHE CRYSTAL STRUCTURE OF A TWO ZINC-FINGER PEPTIDE REVEALS AN EXTENSION TO THE RULES FOR ZINC-FINGER/DNA RECOGNITION
(PROTEIN TRAMTRACK DNA-BINDING DOMAIN)
referenceSchwabe et al.
sourceDrosophila melanogaster
experimentX-ray (resolution=2.80, R-factor=0.193)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHISNCRRDN

Estimated binding specificities ?

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# IC=6.415 IC/col=0.802 n_of_columns=8 specificity:   
A |  38  94   1   0  96   5  65  65
C |  22   1   0   0   0  21  12  10
G |  24   1  95  95   0   7  10  11
T |  12   0   0   1   0  63   9  10
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --QA----TC----RA--SCDC--VT--                 +-----------------------------5yeg_A    
                                             +-1 
  ------HTHGRGTGTT--ACNA--KGRG   L         +-2 +-----------------------------1tf3_A    
                                           ! ! 
  --EC--SCKGRG--LT--FCNA------   L       +-3 +-----------------------------1ubd_C    
                                         ! ! 
  --RGSTDCHGTT--RG--DAEG--RG--   L     +-4 +-----------------------------6b0o_A    
                                       ! ! 
  --QAHTTT--QA--TTLAHGTCDTRG--   L   +-5 +-----------------------------1g2d_F    
                                     ! ! 
  RGST--YGYC----QC--TGSTRGYT--     --6 +-----------------------------4is1_C    
                                     ! 
  --RGSTDCHGTT--RG--DAEG--RG--   L   +-----------------------------5kl3_A    
                                   

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updated Sun Aug 3 06:10:14 2025