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structure nameENGRAILED HOMEODOMAIN Q50K VARIANT DNA COMPLEX
(PROTEIN ENGRAILED HOMEODOMAIN Q50K)
referenceTucker-Kellogg et al. Structure 5 1047 1997
sourceDrosophila melanogaster
experimentX-ray (resolution=1.90, R-factor=0.205)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes2hdd_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRKIKN

Estimated binding specificities ?

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# IC=7.823 IC/col=0.978 n_of_columns=8 specificity:   
A |  14   8   0  68   0   0  96   9
C |  16   0   0  14   0   0   0  73
G |   7  88  96  14   0   0   0   7
T |  59   0   0   0  96  96   0   7
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ENGRAILED
TAATTAPubMed2hdd_A(3.37e-03), 1hdd_CD(1.68e-04), 3hdd_AB(7.09e-04), ... (total=5)
TAATCCPubMed2hdd_A(8.29e-10), 2hdd_AB(8.67e-08), 3hdd_A(3.43e-03), ... (total=4)
TTAATTPubMed2hdd_A(3.37e-03), 3hdd_A(3.43e-03), 1hdd_C(3.41e-03)
TAATNNPubMed2hdd_A(3.37e-03), 3hdd_A(3.43e-03), 1hdd_C(3.41e-03)
TTAATTGCATPubMed3hdd_AB(9.75e-03), 3hdd_A(7.13e-03)

Dendrogram of similar interfaces ?

matrix format
  
  --IAQCNAMG----   L                          +---1b72_A    
                                      +-------2 
  QTVAQTNA------   L                  !       !   +8osb_E    
                                 +----3       +---1 
  --VTKGNA--KA--   L             !    !           +2lkx_A    
                         +-------4    ! 
  --NCRG--------   L     !       !    +-----------4xrm_B    
                       +-5       ! 
  --IAQCNAYC----   L   ! !       +----------------3rkq_B    
                     --6 ! 
  --VTCCNAQA--RT   L   ! +------------------------8g87_X    
                       ! 
  --------YCFAKC       +-------------------------6pe2_B

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updated Fri Sep 13 16:20:58 2024