interface graph thumbnail
legend  pdf

structure nameGR GAMMA DNA-BINDING DOMAIN:FKBP5 16BP COMPLEX-34
(Glucocorticoid receptor)
referenceYamamoto et al. Science 324 407 2009
sourceRattus norvegicus
experimentX-ray (resolution=1.90, R-factor=0.181)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes3g6t_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVR

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |   0   0  13  24  13
C |   0   0  16  24  57
G |   0  96  13  24  13
T |  96   0  54  24  13
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: GR
TGTTCTPubMed3g6t_A(3.59e-04)

Dendrogram of similar interfaces ?

matrix format
  
  --EC----RGRG--RT                              +8hbm_B    
                                 +--------------1 
  ----KGVG----RG--   L     +-----2              +5cbx_B    
                           !     ! 
  --DAKG--RGRG----   L   +-3     +--------------4iqr_B    
                         ! ! 
  CAECKG--KGRG----   L --4 +--------------------6l6q_B    
                         ! 
  CAECKG--KGRG----   L   +----------------------7wnh_D

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updated Fri Sep 13 17:01:38 2024