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structure nameANCGR DNA BINDING DOMAIN - (+)GRE COMPLEX
(ANCGR DNA BINDING DOMAIN)
referenceOrtlund et al. Proc.Natl.Acad.Sci.USA 113 326 2016
sourceUNCLASSIFIED
experimentX-ray (resolution=2.00, R-factor=0.211)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes5cbx_AB 5cbx_EF 5cby_AB
redundant complexes5cby_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVR

Estimated binding specificities ?

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# IC=3.142 IC/col=0.628 n_of_columns=5 specificity:   
A |  16  24  57   0  96
C |  13  24  13  96   0
G |  54  24  13   0   0
T |  13  24  13   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----HG--ECAGKGAAKGRT--   L                            +----------1lo1_A    
                                                        !  
  --CA----EC--KG--KGRG--   L                            !          +1cit_A    
                                                     +-22       +-10  
  --CA----EC--KG--KGRG--   L                         !  !       !  +6l6q_B    
                                                     !  !       !  
  ----HA--EC--KG--RGRG--   L                         !  !       !     +1a6y_A    
                                                     !  +------18     !  
  --------ET--KGAT--RG--   L                         !          !  +-14    +1lat_A    
                                                     !          !  !  !  +-9 
  --------DG--KG--RTRG--   L                         !          !  !  +-13 +3cbb_A    
                                                     !          +-16     !  
  --------EC--KG--KGRG--   L                         !             !     +1ynw_B    
                                                     !             !  
  ------------KAVG--RG--                             !             !  +5va7_A    
                                                     !             +-11  
  ------------KGVT--RG--                             !                +5emc_A    
                                                     !  
  ------------KGVT--RG--                             !                 +1r4i_A    
                                                     !               +-1 
  ------------KGVT--RG--   L                         !             +-2 +5cbz_E    
                                                  +-24             ! ! 
  --------EA--KG--RTRTRT                          !  !         +--17 +2han_B    
                                                  !  !         !   !  
  ------------KAVA--RA--   L                      !  !         !   ! +5e69_A    
                                                  !  !         !   +-4 
  --------EC--KG--KGRG--   L                      !  !     +--19     +3e00_A    
                                                  !  !     !   !  
  ------------KGVT--RG--   L                      !  !     !   !     +2c7a_B    
                                                  !  !     !   !   +-5 
  ------------KGVT--RG--   L                      !  !     !   +--15 +1glu_A    
                                                  !  !  +-21       !  
  --------EC--KG--RGRG--   L                      !  !  !  !       +-3dzy_D    
                                                  !  !  !  !  
  ST------EC--KG--KGRG--   L                      !  !  !  !         +6fbq_A    
                                               +-25  !  !  !  +------3 
  --------EC--KG--KGRA--   L                   !  !  !  !  !  !      +5l0m_A    
                                               !  !  !  !  +-20  
  --------EA--KG--KTRG--   L                   !  !  +-23     !     +2han_A    
                                               !  !     !     +----12  
  --------EC--KG--KGRG--   L                   !  !     !           ! +1r0n_A    
                                               !  !     !           +-7 
  --------DA--KG--RGRG--   L                   !  !     !             +4iqr_B    
                                     +--------26  !     !  
  --------EC--KG--RGRG--   L         !         !  !     !           +2nll_B    
                                     !         !  !     +-----------8 
  --------EA--KG--RTRG--   L         !         !  !                 +1kb2_B    
                                     !         !  !  
  ------------KGVG--RG--   L      +-27         !  !                +4tnt_B    
                                  !  !         !  +----------------6 
  --------EC--KG--KGRG--   L      !  !         !                   +4nqa_H    
                                  !  !         !  
  --------EC--KG--KGRG--   L   +-28  !         +----------------2ff0_A    
                               !  !  !  
  --------EC--KG----RA--   L   !  !  +--------------------------5krb_G    
                             -29  !  
  --------EC--KGAGKGRG--   L   !  +--------------------------1hcq_E    
                               !  
  --------EC--KG--RGRG--   L   +----------------------------1dsz_A    
                             

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updated Fri Sep 13 19:23:41 2024