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structure nameSTRUCTURAL BASIS OF NR4A2 HOMODIMERS BINDING TO SELECTIVE NUR- RESPONSIVE ELEMENTS
(NUCLEAR RECEPTOR RELATED 1)
referenceJiang et al. J.Biol.Chem. 294 19795 2019
sourceHOMO SAPIENS
experimentX-ray (resolution=2.60, R-factor=0.255)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes6l6l_AB 6l6q_AB 6lc1_AD
redundant complexes1cit_A 6l6l_A 6lc1_D
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureCEKKRRR

Estimated binding specificities ?

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# IC=6.338 IC/col=0.704 n_of_columns=9 specificity:   
A |   9  24  24  96   0   0   7   7  73
C |   7  24  24   0   0   0   7  75   7
G |   7  24  24   0  96  96   7   7   9
T |  73  24  24   0   0   0  75   7   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --CAECKG--KGRG----RTRA   L                              +-6l6q_B    
                                                        +-5 
  ----EAKG--RTRTRT------                         +------7 +-2han_B    
                                                 !      ! 
  ----ECKG--KGRG--RC----   L                     !      +--2ff0_A    
                                            +----9 
  ----EAKG--KTRG--------   L                !    !           +2han_A    
                                            !    !         +-1 
  ----ECKG--KGRG--------                    !    +---------2 +3dzy_A    
                                        +--10              ! 
  ----DGKG--RTRG--------   L            !   !              +3cbb_A    
                                        !   !  
  ----ECKG----RA--------   L            !   !          +---5krb_G    
                                        !   !          ! 
  ------KAVA--RA--------   L            !   +----------8    +5e69_A    
                                    +--11              !  +-3 
  ----ECKG--RGRG--------   L        !   !              +--4 +3dzy_D    
                                    !   !                 ! 
  ----ETKGAT--RG--------   L        !   !                 +1lat_A    
                               +---12   !  
  ST--ECKG--KGRG--------   L   !    !   !                +-6fbq_A    
                               !    !   +----------------6 
  ------KGVT--RG--------     -13    !                    +-5emp_A    
                               !    !  
  ------KGVT--RG--------   L   !    +----------------------2c7a_B    
                               !  
  ----ECKGAGKGRG--------   L   +---------------------------1hcq_E    
                             

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updated Wed Dec 18 04:33:40 2024