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legend  pdf

structure nameMULTI-DOMAIN ORGANIZATION OF THE HNF4ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA
(Hepatocyte nuclear factor 4-alpha)
referenceRastinejad et al. Nature 495 394 2013
sourceHomo sapiens
experimentX-ray (resolution=2.90, R-factor=0.241)
structural superfamilyNuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence familyLigandbinding domain of nuclear hormon; Zinc finger, C4 type two domains;
multimeric complexes4iqr_AB 4iqr_EF
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKRRR

Estimated binding specificities ?

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# IC=4.915 IC/col=0.819 n_of_columns=6 specificity:   
A |  73   0   0   9   9  73
C |   7   0   0   7  73   7
G |   7  96  96   7   7   9
T |   9   0   0  73   7   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --EAKG--KTRG--   L                            +4umm_A    
                            +-------------------1 
  ----KGVG--RG--   L        !                   +4tnt_B    
                       +----6 
  ----KGVT--RG--   L   !    !                    +5emc_A    
                       !    !                  +-2 
  --ECKGAGKGRG--   L   !    +------------------3 +1hcq_E    
                       !                       ! 
  --ECKGAG--KTRG   L --7                       +4aa6_B    
                       ! 
  CAECKG--KGRG--   L   !                   +----1cit_A    
                       !      +------------4 
  ----KGVT--RG--   L   +------5            +----2c7a_B    
                              ! 
  --ECKGAG--RG--   L          +-----------------4ond_A    
                     

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updated Mon Jun 29 18:06:57 2026