4iqr_B : 3D-footprint complex

structure name	MULTI-DOMAIN ORGANIZATION OF THE HNF4ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA (Hepatocyte nuclear factor 4-alpha)
reference	Rastinejad et al. Nature 495 394 2013
source	Homo sapiens
experiment	X-ray (resolution=2.90, R-factor=0.241)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence family	Ligandbinding domain of nuclear hormon; Zinc finger, C4 type two domains;
multimeric complexes	4iqr_AB 4iqr_EF
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4iqr_B interface=21,24,28,29,77, alcaicgdratgkhygasscDgcKgffRRsvrknhmyscrfsrqcvvdkdkrnqcrycrlkkcfragmkkeavqneRdristrrssyedsslpsinallqaevlsdirakkiasiadvcesmkeqllvlvewakyipafcelplddqvallrahagehlllgatkrsmvfkdvlllgndyivprhcpelaemsrvsirildelvlpfqelqiddneyaylkaiiffdpdakglsdpgkikrlrsqvqvsledyindrqydsrgrfgelllllptlqsitwqmieqiqfiklfgmakidnllqemllgg
interface signature	DKRRR

Estimated binding specificities ?

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# IC=4.960 IC/col=0.827 n_of_columns=6

specificity:

A |  73   0   0   7   7  75
C |   9   0   0   7  73   7
G |   7  96  96   9   9   7
T |   7   0   0  73   7   7

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Dendrogram of similar interfaces ?

matrix format

  
  --EAKG--KTRG--   L   +-----------------------------4umm_A    
                       ! 
  CAECKG--KGRG--   L   !                        +----1cit_A    
                     --5           +------------2 
  ----KGVT--RG--   L   !   +-------3            +----2c7a_B    
                       !   !       ! 
  --ECKGAG--RG--   L   +---4       +-----------------4ond_A    
                           ! 
  --ECKGAGKGRG--   L       !                        +1hcq_E    
                           +------------------------1 
  --ECKGAG--KTRG   L                                +4aa6_B

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updated Sat Jan 10 07:10:06 2026