7wnh_D : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF NURR1 BINDING TO NBRE (Nuclear receptor subfamily 4 group A member 2)
reference	Zhao et al. Proc.Natl.Acad.Sci.USA 119 e2206737119 2022
source	Homo sapiens
experiment	X-ray (resolution=3.10, R-factor=0.225)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains; Ligandbinding domain of nuclear hormon;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7wnh_D interface=10,19,22,26,27,80,82, cavcgdnaaCqhygvrtcEgcKgffKRtvqknakyvclankncpvdkrrrnrcqycrfqkclavgmvkevvrtdslkgrRgRlppvslisalvrahvdsnpamtsldysrfqanpsgddtqhiqqfydlltgsmeiirgwaekipgfadlpkadqdllfesaflelfvlrlayrsnpvegklifcngvvlhrlqcvrgfgewidsivefssnlqnmnidisafsciaalamvterhglkepkrveelqnkivnclkdhvtfnngglnrpnylskllgklpelrtlctqglqrifylkledlvpppaiidklfldtl
interface signature	CEKKRRR

Estimated binding specificities ?

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# IC=8.431 IC/col=0.937 n_of_columns=9

specificity:

A |  54  96  24  96   0   0  13   0  96
C |  16   0  24   0   0   0  16  96   0
G |  13   0  24   0  96  96  13   0   0
T |  13   0  24   0   0   0  54   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  CAECKG--KGRG----RTRT   L                 +----1cit_A    
                               +-----------3 
  --ECKGAG--RG--------   L     !           +----4ond_A    
                             +-5 
  --ECKG----RA--------   L   ! !              +-5krb_G    
                             ! +--------------2 
  --EAKG--KTRG--------   L --6                +-4umm_A    
                             ! 
  --EAKG--RTRT--RT----       !                 +4umm_E    
                             !  +--------------1 
  ----KGVT--RG--------   L   +--4              +2c7a_B    
                                ! 
  --ECKGAG--KTRG------   L      +---------------4aa6_B

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updated Sat Jan 10 20:23:46 2026