7wnh_D : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF NURR1 BINDING TO NBRE (Nuclear receptor subfamily 4 group A member 2)
reference	Zhao et al. Proc.Natl.Acad.Sci.USA 119 e2206737119 2022
source	Homo sapiens
experiment	X-ray (resolution=3.10, R-factor=0.225)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains; Ligandbinding domain of nuclear hormon;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7wnh_D interface=10,19,22,26,27,80,82, cavcgdnaaCqhygvrtcEgcKgffKRtvqknakyvclankncpvdkrrrnrcqycrfqkclavgmvkevvrtdslkgrRgRlppvslisalvrahvdsnpamtsldysrfqanpsgddtqhiqqfydlltgsmeiirgwaekipgfadlpkadqdllfesaflelfvlrlayrsnpvegklifcngvvlhrlqcvrgfgewidsivefssnlqnmnidisafsciaalamvterhglkepkrveelqnkivnclkdhvtfnngglnrpnylskllgklpelrtlctqglqrifylkledlvpppaiidklfldtl
interface signature	CEKKRRR

Estimated binding specificities ?

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# IC=8.472 IC/col=0.941 n_of_columns=9

specificity:

A |  57  96  24  96   0   0  13   0  96
C |  13   0  24   0   0   0  13  96   0
G |  13   0  24   0  96  96  16   0   0
T |  13   0  24   0   0   0  54   0   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  CAECKG--KGRG--RTRT   L         +-------------------7wnh_D    
                           +-----2 
  CAECKG--KGRG--RTRA   L   !     +-------------------6l6q_B    
                         --3 
  --EC----RGRGRT----       !                         +8hbm_B    
                           +-------------------------1 
  ----KGVG--RG------   L                             +5cbx_B

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updated Wed Dec 18 13:58:37 2024