7wnh_D : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF NURR1 BINDING TO NBRE (Nuclear receptor subfamily 4 group A member 2)
reference	Zhao et al. Proc.Natl.Acad.Sci.USA 119 e2206737119 2022
source	Homo sapiens
experiment	X-ray (resolution=3.10, R-factor=0.225)
structural superfamily	Nuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains; Ligandbinding domain of nuclear hormon;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7wnh_D interface=10,19,22,26,27,80,82, cavcgdnaaCqhygvrtcEgcKgffKRtvqknakyvclankncpvdkrrrnrcqycrfqkclavgmvkevvrtdslkgrRgRlppvslisalvrahvdsnpamtsldysrfqanpsgddtqhiqqfydlltgsmeiirgwaekipgfadlpkadqdllfesaflelfvlrlayrsnpvegklifcngvvlhrlqcvrgfgewidsivefssnlqnmnidisafsciaalamvterhglkepkrveelqnkivnclkdhvtfnngglnrpnylskllgklpelrtlctqglqrifylkledlvpppaiidklfldtl
interface signature	CEKKRRR

Estimated binding specificities ?

readout + contact

# IC=6.292 IC/col=0.699 n_of_columns=9

specificity:

A |   0   7  24   0   7   7  24   0   7
C |   0   7  24  96  73   7  24   0   7
G |   0  73  24   0   9   7  24   0   9
T |  96   9  24   0   7  75  24  96  73

scan!

Dendrogram of similar interfaces ?

matrix format

  
  CAECKG--KGRG--RTRT   L         +-------------------7wnh_D    
                           +-----2 
  CAECKG--KGRG--RTRA   L   !     +-------------------6l6q_B    
                         --3 
  --EC----RGRGRT----       !                         +8hbm_B    
                           +-------------------------1 
  ----KGVG--RG------   L                             +5cbx_B

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updated Sun Aug 3 21:06:48 2025