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legend  pdf

structure nameMOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
(V2K7E-G19S)
referenceSubramanian et al. 'Nucleic 39 729 2011
sourceCHLAMYDOMONAS REINHARDTII
experimentX-ray (resolution=2.30, R-factor=0.182)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes3mxb_AB 3mxb_RS
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIQKRSNQSATYSVDRSKT

Estimated binding specificities ?

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# IC=11.102 IC/col=0.925 n_of_columns=12 specificity:   
A |   0  16  12   5   0   0  96   0  24  69   0  96
C |   5   6  69  69   0   0   0   0  24   7  96   0
G |   0   5  10  12   0  96   0  96  24  10   0   0
T |  91  69   5  10  96   0   0   0  24  10   0   0
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Dendrogram of similar interfaces ?

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updated Sun Aug  3 07:18:26 2025