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legend  pdf

structure nameMOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
(V2K7E-G19S)
referenceSubramanian et al. 'Nucleic 39 729 2011
sourceCHLAMYDOMONAS REINHARDTII
experimentX-ray (resolution=2.30, R-factor=0.182)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes2vbj_AB 2vbo_AB 2xe0_AB 3mxb_AB 3mxb_RS 6fb0_AB 6fb5_AB
reference complex2vbo_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIQKRSNQSATYSVDRSKT

Estimated binding specificities ?

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# IC=11.119 IC/col=0.927 n_of_columns=12 specificity:   
A |   0   0   6  24   0   0   0  96  10   0  65  80
C |   0   0   5  24  96   0  96   0   1  11  10   6
G |   0  96  10  24   0   0   0   0  75  75   5   5
T |  96   0  75  24   0  96   0   0  10  10  16   5
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Dendrogram of similar interfaces ?

matrix format



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updated Thu Jan  8 22:21:15 2026