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legend  pdf

structure nameMOLECULAR BASIS OF ENGINEERED MEGANUCLEASE TARGETING OF THE ENDOGENOUS HUMAN RAG1 LOCUS
(V2K7E-G19S)
referenceSubramanian et al. 'Nucleic 39 729 2011
sourceCHLAMYDOMONAS REINHARDTII
experimentX-ray (resolution=2.30, R-factor=0.182)
structural superfamilyHoming endonucleases;
sequence familyLAGLIDADG endonuclease;
multimeric complexes2xe0_AB 3mxb_AB 3mxb_RS 6fb0_AB 6fb5_AB
reference complex6fb0_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSIQKRSNQSATYSVDRSKT

Estimated binding specificities ?

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# IC=11.067 IC/col=0.922 n_of_columns=12 specificity:   
A |   0  10  10   5   0   0  96   0  24  69   0  96
C |   6   5  69  71   0   0   0   0  24   5  96   0
G |   5   5  12  10   0  96   0  96  24  12   0   0
T |  85  76   5  10  96   0   0   0  24  10   0   0
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Dendrogram of similar interfaces ?

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updated Sun Jun 28 07:56:26 2026