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legend  pdf

structure nameCRYSTAL STRUCTURE OF CAMP RECEPTOR PROTEIN FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH CAMP AND ITS DNA BINDING ELEMENT
(PROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN PROBABLY CRPFNR-FAMILY)
referenceWilmanns et al. 'To ? ? ?
sourceMycobacterium tuberculosis
experimentX-ray (resolution=2.90, R-factor=0.248)
structural superfamilycAMP-binding domain-like;"Winged helix" DNA-binding domain;
sequence familyCyclic nucleotidebinding domain; Bacterial regulatory proteins, crp famil;
multimeric complexes3mzh_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSRETNK

Estimated binding specificities ?

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# IC=3.627 IC/col=0.725 n_of_columns=5 specificity:   
A |   7   7  73   7  96
C |   7  75   7  73   0
G |   9   7   7   7   0
T |  73   7   9   9   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: CAMP
TCACAPubMed3mzh_A(2.57e-08), 3mzh_AB(3.34e-05)
TGTGAPubMed3mzh_A(2.57e-08), 3mzh_AB(3.34e-05)
TGTGANPubMed3mzh_A(1.20e-07), 3mzh_AB(3.68e-04)
TGACATCAPubMed3mzh_A(8.60e-03)
TGATGTCAPubMed3mzh_A(8.60e-03)
AAATGTGATCTAGATCACATTTPubMed3mzh_A(8.03e-05), 3mzh_AB(2.28e-04)
term: CRP
TGTGAPubMed3mzh_A(2.57e-08), 3mzh_AB(3.34e-05)
TGCGAPubMed3mzh_A(9.98e-04)
TCACAPubMed3mzh_A(2.57e-08), 3mzh_AB(3.34e-05)

Dendrogram of similar interfaces ?

matrix format
  
  ----STRGECTANGKG----   L                             +--3mzh_A    
                                         +-------------1 
  ----HT--STATSTRG----   L     +---------2             +--5lej_A    
                               !         ! 
  ----HTHTVATAST------   L   +-3         +----------------3e6c_C    
                             ! ! 
  ETNTSCRGHC--RT----QA     --4 +--------------------------5d4s_B    
                             ! 
  --------------RCYG--       +---------------------------2acj_B

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updated Fri Sep 13 17:30:15 2024