3n97_A : 3D-footprint complex

structure name	RNA POLYMERASE ALPHA C-TERMINAL DOMAIN (E. COLI) AND SIGMA REGION 4 (T. AQ. MUTANT) BOUND TO (UP,-35 ELEMENT) DNA (RNA POLYMERASE SIGMA FACTOR)
reference	Lara-Gonzalez et al. Biochemistry 59 4523 2020
source	THERMUS AQUATICUS
experiment	X-ray (resolution=3.25, R-factor=0.257)
structural superfamily	Sigma3 and sigma4 domains of RNA polymerase sigma factors;
sequence family	Sigma70, region 4;
multimeric complexes	3n97_ABC
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 3n97_A interface=25,26,35,36,37,38,40,41, sklsereamvlkmrkglidgrehtLEevgayfgvTRERiRQienkalrklrhp
interface signature	LETRERRQ

Estimated binding specificities ?

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# IC=5.068 IC/col=1.014 n_of_columns=5

specificity:

A |   4   3   6   0  96
C |  81   3   6   0   0
G |   4   3   6  96   0
T |   7  87  78   0   0

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Dendrogram of similar interfaces ?

matrix format

  
  ----RCEC----QT             +-----------------------------6wmr_Z    
                           +-1 
  LTTTRGECRCRTQC   L     +-2 +-----------------------------4xln_F    
                         ! ! 
  --TT--PTTCSTNT   L   +-3 +-----------------------------4lln_I    
                       ! ! 
  --STRGQTQAST--   L --4 +-----------------------------7t8k_B    
                       ! 
  --HCRGRGQAQGKG   L   +-----------------------------2glo_A

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updated Fri Sep 13 17:30:34 2024