interface graph thumbnail
legend  pdf

structure nameASYMMETRIC ASSEMBLY OF MERKEL CELL POLYOMAVIRUS LARGE T-ANTIGEN ORIGIN BINDING DOMAINS AT THE VIRAL ORIGIN
(Large T antigen)
referenceHarrison et al. J.Mol.Biol. 409 529 2011
sourceMerkel cell polyomavirus
experimentX-ray (resolution=2.90, R-factor=0.228)
structural superfamilyOrigin of replication-binding domain, RBD-like;
sequence familyOrigin of replication binding protein;
multimeric complexes3qfq_ABE
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSNKTR

Estimated binding specificities ?

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# IC=3.780 IC/col=0.630 n_of_columns=6 specificity:   
A |  92   1  14   3  19  13
C |   1   1  54  87  20  56
G |   1  93  14   3  19  13
T |   2   1  14   3  38  14
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --SANGKGTC------------RG----------------------   L                               +3qfq_B    
                                                                 +-----------------1 
  FGSANGRGTC------------RG----------------------   L     +-------2                 +4gdf_A    
                                                         !       ! 
  ------------------------FTKAHGIAEAACKC----NC--       +-3       +-----------------6wdz_D    
                                                       ! ! 
  ----------KATGTGSGVGFA------RA--ECACKCSCTA----   L --4 +-------------------------5tkz_B    
                                                       ! 
  --------------------------------------------YG       +--------------------------7rbh_A    
                                                     

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updated Mon Jun 29 16:53:47 2026