interface graph thumbnail
legend  pdf

structure nameA CRYSTAL STRUCTURE OF SV40 LARGE T ANTIGEN
(Large T antigen)
referenceChang et al. 'Cell 3 1117 2013
sourceSimian virus 40
experimentX-ray (resolution=2.80, R-factor=?)
structural superfamilyP-loop containing nucleoside triphosphate hydrolases;Origin of replication-binding domain, RBD-like;
sequence familyPolyomavirus large T antigen Cterminu; Origin of replication binding protein;
multimeric complexes2itl_AB 2ntc_AB 4fgn_AB 4gdf_AB 4gdf_EF 5d9i_AB
reference complex2itl_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureFSNRTRQWNH

Estimated binding specificities ?

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# IC=6.407 IC/col=0.915 n_of_columns=7 specificity:   
A |   8   0   0   0   8   0   8
C |   8   0  96  80   8  96   8
G |  72  96   0   8   8   0   8
T |   8   0   0   8  72   0  72
scan!

Dendrogram of similar interfaces ?

matrix format
  
  FGSANGRGTC----------RGQGWANTHC   L                +-----------------4gdf_A    
                                             +------1 
  ----------------------------HT           +-2      +-----------------2gxa_L    
                                           ! ! 
  --SANGKGTC----------RG--------   L     +-3 +------------------------3qfq_B    
                                         ! ! 
  --SGNGKGTC----------RG--------   L   +-4 +--------------------------4fb3_A    
                                       ! ! 
  NT--KTTTTC--------------------     --5 +---------------------------1ksy_A    
                                       ! 
  ----------NCKGCAYTRC----------   L   +----------------------------1jj4_B

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updated Fri Jan 9 00:39:49 2026