4m9v_C : 3D-footprint complex

structure name	ZFP57 MUTANT (E182Q) IN COMPLEX WITH 5-CARBOXYLCYTOSINE DNA (Zinc finger protein 57)
reference	Olanrewaju et al. Biochemistry 52 9310 2013
source	Mus musculus
experiment	X-ray (resolution=0.97, R-factor=0.131)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
redundant complexes	4gzn_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4m9v_C interface=17,18,19,22,23,44,45,47,48,51, pserpffcnfcgktyrDASglSRhrrahlgyrprscpecgkcfRDqSQvnRhlkvhqnkp
interface signature	DASSRRDSQR

Estimated binding specificities ?

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# IC=6.308 IC/col=1.051 n_of_columns=6

specificity:

A |   0   0   3   2   9  96
C |   0   0  85   4  67   0
G |   0  96   5  88   9   0
T |  96   0   3   2  11   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ZFP57
TGCCGC	PubMed	4gzn_C(8.36e-10)
GCGGCA	PubMed	4gzn_C(8.36e-10)

Dendrogram of similar interfaces ?

matrix format

  
  ------HCHGRG--TA--ACNA--KGRG   L                            +1tf6_A    
                                         +--------------------1 
  ------HTHGRGTGTT--ACNA--KGRG   L       !                    +1tf3_A    
                                     +---5 
  --VT----NARG------ETTG------       !   !    +---------------6e94_A    
                                     !   +----3 
  QT--AG--KGRG--RG--DCKG------   L   !        !          +----7n5w_A    
                                   --6        +----------2 
  RGST--YGYC----QC--TGSTRGYT--       !                   +----4is1_C    
                                     ! 
  --DG--YCKGRG--QA----TC------   L   !        +---------------5k5h_A    
                                     +--------4 
  --NT--STNAVT--QTSTSGKG--RG--   L            +---------------6u9q_A

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updated Fri Sep 13 18:31:29 2024