interface graph thumbnail
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structure nameHUMAN TFIIB-RELATED FACTOR 2 (BRF2) AND TBP BOUND TO U6#2 PROMOTER
(TATA-BOX-BINDING PROTEIN)
referenceGuthertz et al. 'Cell(Cambridge,Mass.)' 163 1375 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=1.90, R-factor=0.187)
structural superfamilyTATA-box binding protein-like;
sequence familyTranscription factor TFIID or TATAbinding;
multimeric complexes1c9b_AEIM 1c9b_QR 1jfi_ABC 1nvp_AC 4roc_AB 4rod_AB 4roe_AB
redundant complexes5n9g 1tgh 4rod 4roe 1cdw 1nvp 1jfi 1c9b
reference complex1cdw_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNVFLFVTNVFPLFVT

Estimated binding specificities ?

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# IC=7.965 IC/col=0.996 n_of_columns=8 specificity:   
A |   9  96   9   0   0   9  96  96
C |   9   0  11   0   0  11   0   0
G |  11   0   9   0   0   9   0   0
T |  67   0  67  96  96  67   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  NTVAFT--LTFAVATT--NAVTFAPALAFTVATA--   L     +-----------------------------1vto_B    
                                             +-6 
  NTVAFG--LTFAVA----NAVTFAPALTFTVATA--   L   ! +-----------------------------5iyd_P    
                                             ! 
  NTVTFA--LAFTVATT--NAVTFTPALTFAVTTA--   L   !                              +4roc_B    
                                             !                            +-1 
  NAVTFTPALTFAVATA--NTVTFTPALTFAVAST--   L --7                   +--------2 +1ais_A    
                                             !                   !        ! 
  NAVTFT--LTFAVATA--NTVTFAPALAFTVATA--   L   !      +------------3        +1ytb_A    
                                             !      !            ! 
  NTVTFT--LTFAVATT--NAVTFTPALTFAVATA--   L   ! +----4            +---------1qna_B    
                                             ! !    ! 
  NTVAFA--LAFTVGTTQGNTVAFAPALAFTVATT--   L   +-5    +----------------------6cnc_R    
                                               ! 
  ----------------------------------RT         +---------------------------6mup_M    
                                           

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updated Thu Sep 12 20:03:17 2024