interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HUMAN HSF1 WITH SATELLITE III REPEAT DNA
(Heat shock factor protein 1)
referenceHayer-Hartl et al. Nat.Struct.Mol.Biol. 23 140 2016
sourceHomo sapiens
experimentX-ray (resolution=2.55, R-factor=0.192)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyHSFtype DNAbinding;
multimeric complexes5d5v_BD
redundant complexes5d5u_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSVRQNMR

Estimated binding specificities ?

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# IC=5.300 IC/col=0.757 n_of_columns=7 specificity:   
A |   9   0   0  96  67  24   9
C |   9   0   0   0   9  24   9
G |  11  96  96   0  11  24  67
T |  67   0   0   0   9  24  11
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HSF1
CCAATPubMed5d5v_BD(1.81e-03)
AGAACGTTCTAGAACPubMed5d5u_B(1.27e-02)

Dendrogram of similar interfaces ?

matrix format
  
  ----ECKTRGHTRA   L                         +---4mhg_A    
                                           +-1 
  ------KTRGYT--   L   +-------------------2 +---4bqa_A    
                       !                   ! 
  ------KTRGYA--   L --3                   +-----4l18_B    
                       ! 
  ITSCSGKG------   L   +-------------------------5i2d_R

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updated Fri Sep 13 19:26:22 2024