interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF E. COLI CASCADE BOUND TO A PAM-CONTAINING DSDNA TARGET AT 2.45 ANGSTROM RESOLUTION.
(CRISPR SYSTEM CASCADE SUBUNIT CASC)
referencevan Erp et al. Nature 530 499 2016
sourceESCHERICHIA COLI (STRAIN K12) / ESCHERICHIA COLI (STRAIN K12)
experimentX-ray (resolution=2.45, R-factor=0.206)
sequence familyCT1975like protein;
multimeric complexes4qyz_ABCDEFGHIJ 5h9e_AC 5h9e_BDEFGHIJ 5h9f_ACI 5h9f_BDEFGHJ
redundant complexes4qyz 5h9e
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureAMTFQSHL

Estimated binding specificities ?

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# IC=8.431 IC/col=0.649 n_of_columns=13 specificity:   
A |  13   0  96   0   0  24  24  24  24  24  54  96   0
C |  54  96   0   0   0  24  24  24  24  24  13   0  96
G |  16   0   0  96  96  24  24  24  24  24  16   0   0
T |  13   0   0   0   0  24  24  24  24  24  13   0   0
scan!

Dendrogram of similar interfaces ?

matrix format



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updated Sat Jan 10 08:11:15 2026