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structure nameSTRUCTURE OF LHX4 TRANSCRIPTION FACTOR COMPLEXED WITH DNA
(LIMhomeobox protein Lhx4)
referenceMorgunova et al. Science 356 ? 2017
sourceHomo sapiens
experimentX-ray (resolution=2.68, R-factor=0.235)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5hod_AD
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRVQN

Estimated binding specificities ?

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# IC=1.468 IC/col=0.210 n_of_columns=7 specificity:   
A |   8  12  60  56  21  24  38
C |   8  12  12  13  21  24  19
G |  72  12  12  13  21  24  19
T |   8  60  12  14  33  24  20
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Dendrogram of similar interfaces ?

matrix format
  
  ------RT------------VAQTNA------   L                                 +5hod_A    
                                                                     +-1 
  --KG--RT------------IAQCNAYA--RT   L                  +------------3 +1nk2_P    
                                                        !            ! 
  --RC--RT------------NT--NAITRG--                   +--7            +-5zjt_B    
                                                     !  ! 
  --RT--RT------------IAKGNA------   L               !  +--------------6m3d_C    
                                                 +---8 
  ------RA----------RCVTCTNAQTRC--   L           !   !     +-----------1au7_A    
                                                 !   !     ! 
  RC----RT------------ITQCNAACRG--   L           !   +-----6           +6a8r_A    
                                                 !         !         +-2 
  ----RC----RT--------NCSTNARG----   L         +-9         +---------4 +1mnm_C    
                                               ! !                   ! 
  ------RT------------NT--NAIARG--   L         ! !                   +-1b72_B    
                                               ! ! 
  ------RT----------FTYAQTNAATRG--   L      +-10 !                +----6ryd_F    
                                            !  ! +----------------5 
  ------------------RTVAITNAMCRG--   L      !  !                  +----1yrn_A    
                                         +-11  !  
  --------NGRGTGLGLC--------------       !  !  +-----------------------6vjw_A    
                                       -12  !  
  ------RA------------YAQTNAAARG--   L   !  +------------------------6wig_A    
                                         !  
  ------------------RCVACTNAQA----   L   +-------------------------7xrc_C    
                                       

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updated Fri Sep 13 19:45:19 2024