interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF LHX4 TRANSCRIPTION FACTOR COMPLEXED WITH DNA
(LIMhomeobox protein Lhx4)
referenceMorgunova et al. Science 356 ? 2017
sourceHomo sapiens
experimentX-ray (resolution=2.68, R-factor=0.235)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes5hod_AD
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRVQN

Estimated binding specificities ?

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# IC=1.468 IC/col=0.210 n_of_columns=7 specificity:   
A |   8  12  60  56  21  24  38
C |   8  12  12  13  21  24  19
G |  72  12  12  13  21  24  19
T |   8  60  12  14  33  24  20
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RARA--IAQTNA----   L                         +-5ego_B    
                         +---------------------1 
  --RT--NT--NAIARG   L   !                     +-1b72_B    
                       --3 
  RCRT--VTQTNA--RG   L   !                   +---8ejp_B    
                         +-------------------2 
  ----RTNT--NAIARG   L                       +---4cyc_B

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updated Sat Jan 10 08:12:26 2026