interface graph thumbnail
legend  pdf

structure nameTRANSCRIPTION FACTOR FOSB/JUND BZIP DOMAIN IN COMPLEX WITH COGNATE DNA, TYPE-I CRYSTAL
(TRANSCRIPTION FACTOR JUN-D)
referenceMachius et al. 'Nucleic 45 11425 2017
sourceHOMO SAPIENS
experimentX-ray (resolution=2.05, R-factor=0.219)
structural superfamilyLeucine zipper domain;A DNA-binding domain in eukaryotic transcription factors;
sequence familybZIP transcription factor; Basic region leucine zipper;
redundant complexes5vpf_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKNRAACR

Estimated binding specificities ?

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# IC=1.399 IC/col=0.350 n_of_columns=4 specificity:   
A |   9  11  70  15
C |   9  61   9  45
G |  10  12  10  13
T |  68  12   7  23
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOSB
TGACTCAPubMed5vpf_B(7.12e-07)
TGACGCAAPubMed5vpf_B(9.79e-03)
term: JUND
TGCGTCAPubMed5vpf_B(6.08e-03)
TGAGTCAPubMed5vpf_B(7.12e-07)
TTGCGTGPubMed5vpf_B(6.08e-03)
TCACGTGAPubMed5vpe_D(3.43e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----RG------NC--YGAT--CTRG   L              +--------2wt7_B    
                                         +----2 
  RA----NA----AAVT--STRG----   L         !    +--------1h89_A    
                                   +-----3 
  ------NC----AAAT----RT----   L   !     !             +1a02_F    
                                 --4     +-------------1 
  --QC----FTRC--------------   L   !                   +7aw7_D    
                                   ! 
  ------RA----NT--AAVT--STRG   L   +-------------------1hjb_A

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updated Fri Sep 13 20:38:18 2024