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structure nameSTRUCTURE OF THE TN1549 TRANSPOSON INTEGRASE (AA 82-397, R225K) IN COMPLEX WITH A CIRCULAR INTERMEDIATE DNA (CI6B-DNA)
(Int protein)
referenceRubio-Cosials et al. Cell 173 208 2018
sourceEnterococcus faecalis
experimentX-ray (resolution=2.67, R-factor=0.188)
structural superfamilyDNA breaking-rejoining enzymes;
sequence familyPhage integrase family;
multimeric complexes6emz_AB 6en0_AB 6en1_AB 6en2_AB
redundant complexes6emz 6en1 6en0
reference complex6en1_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNTRKTNRSTAVDR

Estimated binding specificities ?

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# IC=10.083 IC/col=0.840 n_of_columns=12 specificity:   
A |   5  24  12  24  67  79  84   0   0   0   0   0
C |  79  24   0  24   5   7   5   0   0   0   0  96
G |   7  24  11  24  11   5   0   0   0   0   0   0
T |   5  24  73  24  13   5   7  96  96  96  96   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  NATA------RT----KTTT----NA--RCSAKG--YG--------TA------ATVTDT----------RC----------   L                    +----------6en2_A    
                                                                                                          +-1 
  KGTA--NAYASG----ATST----LT------------------------RCST----TTSTRGYC----------TT--QT   L          +-------2 +----------1z19_B    
                                                                                                  !       ! 
  ----------------AATA--KGNA--IT----------------------TTQAATYGYAKT--------------TT--   L        +-3       +-----------5jk0_B    
                                                                                                ! ! 
  HTTTKGMT--ST----------KATT--QT----QT------------RT--------STRG----EA--------------   L   +----4 +-------------------1xo0_B    
                                                                                           !    ! 
  ------------------------------------------------------IT--------RT------RT--------   L --5    +-------------------4e0p_A    
                                                                                           ! 
  KATT--AAYT--WTTTKATTQTSTLTLTNT--ST----LTLTRTST----------------------QA----DCKCTC--   L   +------------------------2a3v_C    
                                                                                         

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updated Thu Sep 12 23:13:23 2024