interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF THE TN1549 TRANSPOSON INTEGRASE (AA 82-397, R225K) IN COMPLEX WITH A CIRCULAR INTERMEDIATE DNA (CI6A-DNA)
(Int protein)
referenceRubio-Cosials et al. Cell 173 208 2018
sourceEnterococcus faecalis
experimentX-ray (resolution=2.67, R-factor=0.191)
structural superfamilyDNA breaking-rejoining enzymes;
sequence familyPhage integrase family;
multimeric complexes6emz_AB 6en0_AB 6en1_AB 6en2_AB
redundant complexes6emz_B 6en0_A 6en2_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNTRKTNRSTAVDRNM

Estimated binding specificities ?

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# IC=10.913 IC/col=0.909 n_of_columns=12 specificity:   
A |  96  96  96  96  96   4   4  13  15  57  24   0
C |   0   0   0   0   0   4   4   4   8  13  24   0
G |   0   0   0   0   0   4   4  13   4  13  24  96
T |   0   0   0   0   0  84  84  66  69  13  24   0
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Dendrogram of similar interfaces ?

matrix format
  
  NATA----RTKTTT--NARASA--YT----TA----ATVTDT--------RC----NT----MT   L                     +----------6en1_A    
                                                                                 +---------2 
  KATA--NA--ATST--LT----------------------TTSTRGYC----------------   L           !         +----------1z1b_B    
                                                                           +-----4 
  HTTTKGMTST----KATTQT--QT--------RTST--RG--EA--------------------   L     !     ! +------------------1xo0_B    
                                                                           !     +-3 
  ------------------------------------IT----ST------------DA--EATT   L     !       !                  +4e0g_A    
                                                                         +-6       +------------------1 
  ------------------------------------IT----------------NADA--EATT   L   ! !                          +4f43_A    
                                                                         ! ! 
  --------------------------FCKC--------------NT--RGSTKT----------   L --7 !  +-----------------------1flo_A    
                                                                         ! +--5 
  ----------------------------------RT--ET------------------------       !    +-----------------------6gys_E    
                                                                         ! 
  ----------------------------------------------------------TG----   L   +----------------------------2v6e_B    
                                                                       

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updated Fri Sep 13 21:36:08 2024