interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF SMAD2 WITHOUT EXON -MH1 BOUND TO THE CAGAC SITE.
(Mothers against decapentaplegic homolog)
referenceKaczmarska et al. 'Genes ? ? 2020
sourceHomo sapiens
experimentX-ray (resolution=2.75, R-factor=0.202)
structural superfamilySMAD MH1 domain;
sequence familyMH1 domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQK

Estimated binding specificities ?

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# IC=2.104 IC/col=0.351 n_of_columns=6 specificity:   
A |   4  12  13  13   9  19
C |   4  12  13  57   9  20
G |   7  60  14  13   9  38
T |  81  12  56  13  69  19
scan!

Dendrogram of similar interfaces ?

matrix format
  
  DCRGQCKG   L     +-----------------------------6tbz_A    
                 +-2 
  ----QCKG       ! !                             +5mey_A    
               --3 +-----------------------------1 
  --RGQCKG   L   !                               +5nm9_A    
                 ! 
  --RGQAKG   L   +-----------------------------3kmp_A

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updated Sun Aug 3 11:29:35 2025