6h3r_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF SMAD2 WITHOUT EXON -MH1 BOUND TO THE CAGAC SITE. (Mothers against decapentaplegic homolog)
reference	Kaczmarska et al. 'Genes ? ? 2020
source	Homo sapiens
experiment	X-ray (resolution=2.75, R-factor=0.202)
structural superfamily	SMAD MH1 domain;
sequence family	MH1 domain;
multimeric complexes	1mhd_AB 1ozj_AB
reference complex	5od6_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6h3r_A interface=65,67,72, sspvvkrllgwkksngqeekwsekavkslvkklkktgrldelekaittqnmntkcvtiprsldgRlQvshrKglphviycrlwrwpdlhshhelkaienceyafnlkkdevcvnpyhyqrv
interface signature	RQK

Estimated binding specificities ?

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# IC=2.104 IC/col=0.351 n_of_columns=6

specificity:

A |   4  12  13  13   9  19
C |   4  12  13  57   9  20
G |   7  60  14  13   9  38
T |  81  12  56  13  69  19

scan!

Dendrogram of similar interfaces ?

matrix format

  
  DCRGQCKG   L     +-----------------------------6tbz_A    
                 +-2 
  ----QCKG       ! !                             +5mey_A    
               --3 +-----------------------------1 
  --RGQCKG   L   !                               +5nm9_A    
                 ! 
  --RGQAKG   L   +-----------------------------3kmp_A

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updated Fri Jan 9 06:30:42 2026