interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN FLI1 AND RUNX2 IN COMPLEX WITH 16-MER DNA CAGAGGATGTGGCTTC
(RUNT-RELATED TRANSCRIPTION FACTOR 2)
referenceTsodikov et al. Structure 29 404 2021
sourceHOMO SAPIENS
experimentX-ray (resolution=4.31, R-factor=0.274)
structural superfamilyp53-like transcription factors;
sequence familyRunt domain;
multimeric complexes6vg8_AD
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVDRR

Estimated binding specificities ?

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# IC=8.247 IC/col=1.031 n_of_columns=8 specificity:   
A |  12   0   0   0   0  12   0   0
C |  12   0   0   0   0  60   0   0
G |  12  96   0  96  96  12  12   0
T |  60   0  96   0   0  12  84  96
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RG--RAVCDC----RT   L                             +6vgd_D    
                                +------------------1 
  RG--RTVCDC----RG   L          !                  +3wu1_A    
                         +------3 
  ------STNT----QT       !      !                  +1bg1_A    
                       --4      +------------------2 
  KC----STNTVGSTQT   L   !                         +1bf5_A    
                         ! 
  --RG--TTAT------       +--------------------------4a04_B    
                       

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updated Sat Sep 14 00:06:41 2024