6vg8_D : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN FLI1 AND RUNX2 IN COMPLEX WITH 16-MER DNA CAGAGGATGTGGCTTC (RUNT-RELATED TRANSCRIPTION FACTOR 2)
reference	Tsodikov et al. Structure 29 404 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=4.31, R-factor=0.274)
structural superfamily	p53-like transcription factors;
sequence family	Runt domain;
multimeric complexes	6vg8_AD
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vg8_D interface=21,83,111,112,115,118, aelvrtdspnflcsvlpshwRcnktlpvafkvvalgevpdgtvvtvmagndenysaelrnasavmknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikvtVDgpRepRrh
interface signature	RRVDRR

Estimated binding specificities ?

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# IC=8.431 IC/col=1.054 n_of_columns=8

specificity:

A |  96  96  13   0   0  96   0  54
C |   0   0  16  96  96   0  96  13
G |   0   0  54   0   0   0   0  16
T |   0   0  13   0   0   0   0  13

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Dendrogram of similar interfaces ?

matrix format

  
  RG--RAVCDC----RT   L                             +6vgd_D    
                                +------------------1 
  RG--RTVCDC----RG   L          !                  +3wu1_A    
                         +------3 
  ------STNT----QT       !      !                  +1bg1_A    
                       --4      +------------------2 
  KC----STNTVGSTQT   L   !                         +1bf5_A    
                         ! 
  --RG--TTAT------       +--------------------------4a04_B

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updated Sun Aug 3 13:47:42 2025