6vg8_D : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN FLI1 AND RUNX2 IN COMPLEX WITH 16-MER DNA CAGAGGATGTGGCTTC (RUNT-RELATED TRANSCRIPTION FACTOR 2)
reference	Tsodikov et al. Structure 29 404 2021
source	HOMO SAPIENS
experiment	X-ray (resolution=4.31, R-factor=0.274)
structural superfamily	p53-like transcription factors;
sequence family	Runt domain;
multimeric complexes	6vg8_AD
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vg8_D interface=21,83,111,112,115,118, aelvrtdspnflcsvlpshwRcnktlpvafkvvalgevpdgtvvtvmagndenysaelrnasavmknqvarfndlrfvgrsgRgksftltitvftnppqvatyhraikvtVDgpRepRrh
interface signature	RRVDRR

Estimated binding specificities ?

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# IC=8.247 IC/col=1.031 n_of_columns=8

specificity:

A |  12   0   0   0   0  12   0   0
C |  12   0   0   0   0  60   0   0
G |  12  96   0  96  96  12  12   0
T |  60   0  96   0   0  12  84  96

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RG--RAVCDC----RT   L                             +6vgd_D    
                                +------------------1 
  RG--RTVCDC----RG   L          !                  +3wu1_A    
                         +------3 
  ------STNT----QT       !      !                  +1bg1_A    
                       --4      +------------------2 
  KC----STNTVGSTQT   L   !                         +1bf5_A    
                         ! 
  --RG--TTAT------       +--------------------------4a04_B

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updated Sat Jan 10 12:24:01 2026