interface graph thumbnail
legend  pdf

structure nameOCT4/SOX2 PROTEIN:DNA COMPLEX
referenceChojnowski et al. 'To ? ? ?
experimentX-ray (resolution=2.50, R-factor=0.254)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyPou domain Nterminal to homeobox domain;
multimeric complexes3l1p_AB 6ht5_DE 8bx1_AE 8bx2_AE
redundant complexes3l1p_A 8bx2_A 6ht5
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQSQTTSRVSNQ

Estimated binding specificities ?

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# IC=8.757 IC/col=0.876 n_of_columns=10 specificity:   
A |   6  96   0   6   0  24  64  96  82   6
C |  75   0   6   0  96  24  13   0   0   0
G |   6   0   0  84   0  24   6   0   1  82
T |   9   0  90   6   0  24  13   0  13   8
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updated Sun Aug 3 23:25:44 2025