8c7s_A : 3D-footprint complex

structure name	TRANSCRIPTIONAL PLEIOTROPIC REPRESSOR CODY FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH ILE, GTP, AND A 30-BP DNA FRAGMENT ENCOMPASSING TWO OVERLAPPING BINDING SITES (Global transcriptional regulator CodY Fragment)
reference	Sauer-Eriksson et al. 'Nucleic 51 7631 2023
source	Staphylococcus aureus (strain USA300) / Staphylococcus aureus (strain USA300)
experiment	X-ray (resolution=3.05, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	CodY GAFlike domain; CodY helixturnhelix domain;
multimeric complexes	8c7s_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8c7s_A interface=214,215,218,237, msllsktrelntllqkhkgiavdfkdvaqtissvtvtnvfivsrrgkilgsslnellksqriiqmleerhipseyterlmevkqtesnididnvltvfppenrelfidsrttifpilgggerlgtlvlgrvhddfnendlvlgeyaatvigmeilrekhsevekeardkaaitmainslsysekeaiehifeelggteglliaskvadrvgitRSviVnalrklesagviesrslgMkgtfikvkkekfldeleks
interface signature	RSVM

Estimated binding specificities ?

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# IC=3.947 IC/col=0.564 n_of_columns=7

specificity:

A |  44  88  24  24   0   0   9
C |  24   7  24  24   7   0  66
G |  14   1  24  24   1   0  14
T |  14   0  24  24  88  96   7

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Dendrogram of similar interfaces ?

matrix format

  
  --------YG----------TG--RGSG--FT--   L       +-----------------------------2h27_A    
                                             +-2 
  NTATATRG--------------------------   L     ! +-----------------------------5t01_B    
                                           +-3 
  ----------SGQG--YCNC--------------       ! !                        +----2ve9_C    
                                         --4 +------------------------1 
  --------------ITRGECSC--SGKG------   L   !                          +----5i2d_R    
                                           ! 
  ----------------RGTC--DCVA--RGRCRC   L   +-----------------------------8hih_Q

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updated Sat Jan 10 22:42:55 2026