1a66_A : 3D-footprint complex

structure name	SOLUTION NMR STRUCTURE OF THE CORE NFATC1/DNA COMPLEX, 18 STRUCTURES (CORE NFATC1)
source	HOMO SAPIENS
experiment	NMR
structural superfamily	p53-like transcription factors;
sequence family	Rel homology domain RHD;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1a66_A interface=26,28,29,32,35,125,142,176,177, mkdwqlpshsgpyelrievqpkshhRaRYetEgsRgavkasagghpivqlhgyleneplmlqlfigtaddrllrphafyqvhritgktvsttsheailsntkvleipllpensmravidcagilKlrnsdielrkgetdigRkntrvrlvfrvhvpqpsgrtlslqvasnpiecsQRs
interface signature	RRYERKRQR

Estimated binding specificities ?

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# IC=7.181 IC/col=0.898 n_of_columns=8

specificity:

A |  13  24  13   0   0   0   0   0
C |  13  24  13   0  96  96   0  96
G |  13  24  13   0   0   0   0   0
T |  57  24  57  96   0   0  96   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: NFATC1
CCCTC	PubMed	1a66_A(1.77e-03)

Dendrogram of similar interfaces ?

matrix format

  
  RGRGYT--ECRAKTRTTTQART   L                         +-1a66_A    
                                       +-------------2 
  RG--YTTTECRG--RC--QA--   L   +-------3             +-1p7h_L    
                               !       ! 
  RG--YTTTECRG------QA--   L   !       +---------------1imh_C    
                             --5 
  RGRG----EC--------RG--       !                       +2ram_A    
                               !      +----------------1 
  RGRGYTCTEC------------   L   +------4                +1gji_A    
                                      ! 
  RGRGYA--EC--------KG--   L          +----------------7w7l_B

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updated Sun Aug 3 05:18:03 2025