1cf7_B : 3D-footprint complex

structure name	STRUCTURAL BASIS OF DNA RECOGNITION BY THE HETERODIMERIC CELL CYCLE TRANSCRIPTION FACTOR E2F-DP (PROTEIN TRANSCRIPTION FACTOR DP-2)
reference	Pavletich et al. 'Genes 13 666 1999
source	HOMO SAPIENS
experiment	X-ray (resolution=2.60, R-factor=?)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	E2F/DP family wingedhelix DNAbinding domai;
multimeric complexes	1cf7_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1cf7_B interface=51,54,55,57, gkglrhfsmkvcekvqrkgttsynevadelvseftnsnnhlaadsaydqkNirRRvYdalnvlmamniiskekkeikwiglp
interface signature	NRRY

Estimated binding specificities ?

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# IC=4.853 IC/col=0.971 n_of_columns=5

specificity:

A |  20   0   0   0   1
C |  19  96   0  96   0
G |  19   0  96   0  76
T |  38   0   0   0  19

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: DP-2
TTTCCCGC	PubMed	1cf7_B(1.15e-02), 1cf7_AB(1.05e-03)
TTTCGCGC	PubMed	1cf7_B(2.19e-06), 1cf7_AB(1.45e-07)

Dendrogram of similar interfaces ?

matrix format

  
  NGRGRGYC--------   L                    +------1cf7_B    
                            +-------------1 
  --QA------------   L   +--2             +------2vla_A    
                         !  ! 
  ------------YG--     --3  +--------------------2heo_D    
                         ! 
  ------NASTRGHTST   L   +-----------------------3g73_A

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updated Fri Sep 13 15:29:25 2024