1efa_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF (LAC REPRESSOR)
reference	Bell et al.
source	Escherichia coli
experiment	X-ray (resolution=2.60, R-factor=0.247)
structural superfamily	Periplasmic binding protein-like I;lambda repressor-like DNA-binding domains;
sequence family	Bacterial regulatory proteins, lacI fami; Periplasmic binding proteins and sugar b;
multimeric complexes	1cjg_AB 1efa_AB 1jwl_AB 1l1m_AB 1lbg_AB 1lbg_CD 1osl_AB 2bjc_AB 2kei_AB 2kej_AB 2kek_AB 2pe5_AB
redundant complexes	2kei 2bjc 1lbg 1jwl 1l1m 2kek 1lcd 1osl 2pe5 1cjg 2kej 1lcc
reference complex	1l1m_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1efa_A interface=5,6,15,16,17,20,21,52,55,56, kpvtLYdvaeyagvSYQtvSRvvnqashvsaktrekveaamaelnyipnrvAqqLAgkqslligvatsslalhapsqivaaiksradqlgasvvvsmversgveacktavhnllaqrvsgliinyplddqdaiaveaactnvpalfldvsdqtpinsiifshedgtrlgvehlvalghqqiallagplssvsarlrlagwhkyltrnqiqpiaeregdwsamsgfqqtmqmlnegivptamlvandqmalgamraitesglrvgadisvvgyddtedsscyipplttikqdfrllgqtsvdrllqlsqgqavkgnqllpvslvkrktt
interface signature	LYSYQSRALA

Estimated binding specificities ?

readout + contact

# IC=4.622 IC/col=0.578 n_of_columns=8

specificity:

A |   7  10   0   6  67  13   3  19
C |   7  10   0   6  11  13  85  19
G |   7  63   0  78   9  57   5  39
T |  75  13  96   6   9  13   3  19

scan!

Dendrogram of similar interfaces ?

matrix format

  
  LTYCSTYGQCSTRG--AGLGAC----------   L                            +1efa_A    
                                                                +-1 
  IC--SG--AASTRG--AGLCAC----------   L   +----------------------2 +1rzr_A    
                                         !                      ! 
  ----SG--TC----RG--LCKA----------   L --3                      +1qpz_A    
                                         ! 
  ----------------------LTTTYTYTIT       +-----------------------2w42_B

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updated Thu Jan 8 17:51:42 2026