1ic8_A : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT (HEPATOCYTE NUCLEAR FACTOR 1-ALPHA)
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=0.260)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
sequence family	Hepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 04;
multimeric complexes	1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_A interface=54,55,56,57,59,60,67,159,160,164,167, kelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgtPmktqkraalytwyvrkqrevaqqftharnrfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQPYNNK

Estimated binding specificities ?

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# IC=9.327 IC/col=0.666 n_of_columns=14

specificity:

A |   0   4   0   9   0  24  24  24  24  65  96   6  13   0
C |   0   0   0  13   0  24  24  24  24  13   0  64  24  96
G |   0   6  96  65   0  24  24  24  24   9   0   4   0   0
T |  96  86   0   9  96  24  24  24  24   9   0  22  59   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: HEPATOCYTE 1A
AAATAATGC	PubMed	1ic8_AB(4.62e-05)
CAATT	PubMed	1ic8_A(1.01e-02)
CCAAT	PubMed	1ic8_A(1.01e-02)

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updated Sat Aug 2 00:58:36 2025