1ic8_A : 3D-footprint complex

structure name	HEPATOCYTE NUCLEAR FACTOR 1A BOUND TO DNA : MODY3 GENE PRODUCT (HEPATOCYTE NUCLEAR FACTOR 1-ALPHA)
reference	Dhe-Paganon et al. Mol.Cell 10 1129 2002
source	Homo sapiens
experiment	X-ray (resolution=2.60, R-factor=0.260)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
sequence family	Hepatocyte nuclear factor 1 HNF1, N termi; Homeobox domain 04;
multimeric complexes	1ic8_AB 8pi7_AB 8pi8_AB 8pi9_AB 8pia_AB
reference complex	8pi8_B
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1ic8_A interface=54,55,56,57,59,60,67,159,160,164,167, kelenlspeeaahqkavvetllqedpwrvakmvksylqqhnipqrevvdttglNQSHlSQhlnkgtPmktqkraalytwyvrkqrevaqqftharnrfkwgpasqqilfqayerqknpskeeretlveecnraeciqrgvspsqaqglgsnlvtevrvYNwfaNrrKeea
interface signature	NQSHSQPYNNK

Estimated binding specificities ?

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# IC=10.504 IC/col=0.750 n_of_columns=14

specificity:

A |   0  72  72   0  10  24  24  24  66  96  10   0  85  96
C |   0   3   0   0  10  24  24  24  10   0  77  96   2   0
G |  96  11  24   0   6  24  24  24  10   0   6   0   3   0
T |   0  10   0  96  70  24  24  24  10   0   3   0   6   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: HEPATOCYTE 1A
AAATAATGC	PubMed	1ic8_AB(4.62e-05)
CAATT	PubMed	1ic8_A(1.01e-02)
CCAAT	PubMed	1ic8_A(1.01e-02)

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updated Thu Jan 8 18:03:52 2026