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structure nameESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA
(STEROID HORMONE RECEPTOR ERR2)
sourceHOMO SAPIENS
experimentNMR
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes8ifo_AB
redundant complexes8ifo_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHEAKAKRRR

Estimated binding specificities ?

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# IC=8.431 IC/col=0.843 n_of_columns=10 specificity:   
A |  13   0   0  24  96   0   0   0  24  54
C |  54   0  96  24   0   0   0   0  24  13
G |  13   0   0  24   0  96  96   0  24  13
T |  16  96   0  24   0   0   0  96  24  16
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ESTROGEN RECEPTOR
GGTGACCTTGACCPubMed1lo1_A(1.43e-03)
CATAACCTTGACCPubMed1lo1_A(1.43e-03)
TNAAGGTCAPubMed1lo1_A(7.43e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ECKG--KGRG--RCRC   L      +--------------------------2ff0_A    
                            !  
  EAKG--RTRTRT----          !                     +----4umm_E    
                            !                 +---7 
  --KGVT--RG------          !                 !   !   +1r4i_A    
                            !                 !   +---6 
  ETKGAT--RG------   L      !                 !       ! +1lat_A    
                            !             +---9       +-4 
  ECKG--RGRG------   L   +-12             !   !         +3dzy_D    
                         !  !             !   ! 
  ECKG--KGRG------   L   !  !             !   !        +1ynw_B    
                         !  !         +--10   +--------2 
  ECKG--RGRG------   L   !  !         !   !            +5uan_B    
                         !  !         !   !  
  EAKG--KTRG------   L   !  !         !   !            +2han_A    
                         !  !         !   !       +----1 
  ECKG--RGRG------   L   !  +--------11   +-------8    +2nll_B    
                       -13            !           ! 
  ECKG--KTRG------   L   !            !           +----2nll_A    
                         !            !  
  --KGVT--RG------   L   !            !               +5cbz_E    
                         !            +---------------5 
  DGKG--RTRG------   L   !                            ! +3cbb_A    
                         !                            +-3 
  ECKG--KGRG------       !                              +3dzy_A    
                         !  
  ECKA--RGRG------   L   +-----------------------------4nqa_I    
                       

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updated Fri Sep 13 15:48:17 2024