1u8r_B : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AN IDER-DNA COMPLEX REVEALS A CONFORMATIONAL CHANGE IN ACTIVATED IDER FOR BASE-SPECIFIC INTERACTIONS (Iron-dependent repressor ideR)
reference	Wisedchaisri et al. J.Mol.Biol. 342 1155 2004
source	Mycobacterium tuberculosis
experiment	X-ray (resolution=2.75, R-factor=0.232)
structural superfamily	Iron-dependent repressor protein, dimerization domain;"Winged helix" DNA-binding domain;C-terminal domain of transcriptional repressors;
sequence family	Iron dependent repressor, metal bindin; Iron dependent repressor, Nterminal D; FeoA domain; MarR family;
multimeric complexes	1u8r_ABCD 1u8r_GHIJ
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1u8r_B interface=37,39,40,42,43,47, mnelvdttemylrtiydleeegvtplrariaerldqSgPTvSQtvsRmerdgllrvagdrhleltekgralaiavmrkhrlaerllvdviglpweevhaeacrwehvmsedverrlvkvlnnpttspfgnpipgldelgvglvrltelpagspvavvvrqltehvqgdidlitrlkdagvvpnarvtvettpgggvtivipghenvtlphemahavkvekv
interface signature	SPTSQR

Estimated binding specificities ?

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# IC=5.040 IC/col=0.840 n_of_columns=6

specificity:

A |   0   0  19   0  52  78
C |  96  96  43   0  17  10
G |   0   0  17   0  10   0
T |   0   0  17  96  17   8

scan!

Dendrogram of similar interfaces ?

matrix format

  
  TT----KATTQTTGLTRTKA--FTYT   L         +-----------------------------2p7c_B    
                                       +-1 
  --------------YG----------         +-2 +-----------------------------3eyi_B    
                                     ! ! 
  --DCLT--AGTTRG--RG--------   L   +-3 +-----------------------------5h3r_A    
                                   ! ! 
  ----RGSTRTSTHG------------   L --4 +-----------------------------3zpl_B    
                                   ! 
  --SG--PTPGTT--------HG----   L   +-----------------------------7d98_Q

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updated Sun Aug 3 06:00:12 2025