1w0t_A : 3D-footprint complex

structure name	HTRF1 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA. (TELOMERIC REPEAT BINDING FACTOR 1)
reference	Chapman et al. 'Embo 6 39 2005
source	HOMO SAPIENS
experiment	X-ray (resolution=2.00, R-factor=0.252)
structural superfamily	Homeodomain-like;
sequence family	Myblike DNAbinding domain;
multimeric complexes	1w0t_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1w0t_A interface=2,39,40,43,44,47, kRqawlweedknlrsgvrkygegnwskillhykfnnrtSVmlKDrwRtmkkl
interface signature	RSVKDR

Estimated binding specificities ?

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# IC=4.123 IC/col=0.825 n_of_columns=5

specificity:

A |   0   0   0  10  10
C |   0   0  12  10  10
G |  96  96  74  12  10
T |   0   0  10  64  66

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: HTRF1
TTAGGG	PubMed	1w0t_AB(1.77e-04)
TTTAGGG	PubMed	1w0t_AB(1.69e-03)
GGTTTAG	PubMed	1w0t_A(1.05e-03)

Dendrogram of similar interfaces ?

matrix format

  
  RC--------IAQCNAYC   L     +-----------------------------3rkq_B    
                           +-3 
  RT--------IAQCNAMG   L   ! !                         +---1b72_A    
                           ! +-------------------------2 
  RT------QTVAQTNA--   L --4                           !   +8osb_E    
                           !                           +---1 
  RT--------VTKGNA--   L   !                               +2lkx_A    
                           ! 
  --NARTQT--EC------   L   +-----------------------------2kdz_A

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updated Fri Sep 13 16:06:14 2024