interface graph thumbnail
legend  pdf

structure nameHTRF1 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA.
(TELOMERIC REPEAT BINDING FACTOR 1)
referenceChapman et al. 'Embo 6 39 2005
sourceHOMO SAPIENS
experimentX-ray (resolution=2.00, R-factor=0.252)
structural superfamilyHomeodomain-like;
sequence familyMyblike DNAbinding domain;
multimeric complexes1w0t_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSVKDR

Estimated binding specificities ?

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# IC=4.162 IC/col=0.832 n_of_columns=5 specificity:   
A |   0   0   0  10  10
C |   0   0  10  10  12
G |  96  96  76  10  10
T |   0   0  10  66  64
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HTRF1
TTAGGGPubMed1w0t_AB(1.77e-04)
TTTAGGGPubMed1w0t_AB(1.69e-03)
GGTTTAGPubMed1w0t_A(1.05e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RT------QTVAQTNA--   L                                 +8osb_E    
                                                      +--1 
  RT--------VTKGNA--   L            +-----------------2  +2lkx_A    
                                    !                 ! 
  RT--------IAQCNAMG   L   +--------3                 +--1b72_A    
                           !        ! 
  RC--------IAQCNAYC   L --4        +--------------------3rkq_B    
                           ! 
  --NARTQT--EC------   L   +-----------------------------2kdz_A

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updated Sun Aug 3 06:01:13 2025