1w0t_A : 3D-footprint complex

structure name	HTRF1 DNA-BINDING DOMAIN IN COMPLEX WITH TELOMERIC DNA. (TELOMERIC REPEAT BINDING FACTOR 1)
reference	Chapman et al. 'Embo 6 39 2005
source	HOMO SAPIENS
experiment	X-ray (resolution=2.00, R-factor=0.252)
structural superfamily	Homeodomain-like;
sequence family	Myblike DNAbinding domain;
multimeric complexes	1w0t_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1w0t_A interface=2,39,40,43,44,47, kRqawlweedknlrsgvrkygegnwskillhykfnnrtSVmlKDrwRtmkkl
interface signature	RSVKDR

Estimated binding specificities ?

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# IC=4.075 IC/col=0.815 n_of_columns=5

specificity:

A |  66  64  10   0   0
C |  10  12  74  96  96
G |  10  10  10   0   0
T |  10  10   2   0   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: HTRF1
TTAGGG	PubMed	1w0t_AB(1.77e-04)
TTTAGGG	PubMed	1w0t_AB(1.69e-03)
GGTTTAG	PubMed	1w0t_A(1.05e-03)

Dendrogram of similar interfaces ?

matrix format

  
  RT------QTVAQTNA--   L                                 +8osb_E    
                                         +---------------1 
  RT--------VTKGNA--   L            +----2               +2lkx_A    
                                    !    ! 
  RT--------IAQCNAMG   L   +--------3    +---------------1b72_A    
                           !        ! 
  RC--------IAQCNAYC   L --4        +--------------------3rkq_B    
                           ! 
  --NARTQT--EC------   L   +-----------------------------2kdz_A

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updated Tue Dec 17 22:29:05 2024