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structure nameHUMAN LIVER RECEPTOR HOMOLOGUE DNA-BINDING DOMAIN (HLRH-1 DBD) IN COMPLEX WITH DSDNA FROM THE HCYP7A1 PROMOTER
(Orphan nuclear receptor NR5A2)
referenceMcDonnell et al. J.Mol.Biol. 354 1091 2005
sourceHomo sapiens
experimentX-ray (resolution=2.20, R-factor=0.196)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
redundant complexes5l0m_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKKRRR

Estimated binding specificities ?

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# IC=8.581 IC/col=0.953 n_of_columns=9 specificity:   
A |   0   6  60  96   0   0  19   0  83
C |  12  83  12   0   0   0  57  96   0
G |   1   7  12   0  96  96   8   0   6
T |  83   0  12   0   0   0  12   0   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --EAKG--KTRG--   L     +-----------------------------4umm_A    
                         ! 
  CAECKG--KGRG--   L     !                        +----1cit_A    
                       +-4           +------------1 
  ----KGVT--RG--   L   ! !       +---2            +----2c7a_B    
                       ! !       !   ! 
  --ECKGAG--RG--   L --5 +-------3   +-----------------4ond_A    
                       !         ! 
  --ECKGAG--KTRG   L   !         +---------------------4aa6_B    
                       ! 
  --ECKGAGKGRG--   L   +-----------------------------1hcq_E    
                     

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updated Sat Jan 10 05:07:58 2026