2a66_A : 3D-footprint complex

structure name	HUMAN LIVER RECEPTOR HOMOLOGUE DNA-BINDING DOMAIN (HLRH-1 DBD) IN COMPLEX WITH DSDNA FROM THE HCYP7A1 PROMOTER (Orphan nuclear receptor NR5A2)
reference	McDonnell et al. J.Mol.Biol. 354 1091 2005
source	Homo sapiens
experiment	X-ray (resolution=2.20, R-factor=0.196)
structural superfamily	Glucocorticoid receptor-like DNA-binding domain;
sequence family	Zinc finger, C4 type two domains;
redundant complexes	5l0m_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2a66_A interface=21,24,28,29,79,82, elcpvcgdkvsgyhyglltcEscKgffKRtvqnnkrytcienqncqidktqrkrcpycrfqkclsvgmkleavradrmRggRnkfgpmykrdral
interface signature	EKKRRR

Estimated binding specificities ?

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# IC=7.389 IC/col=0.821 n_of_columns=9

specificity:

A |   0  14  61  96   0   0  24   0  73
C |   7  61  14   0   0   0  24  96   7
G |   8   7   7   0  96  96  24   0   7
T |  81  14  14   0   0   0  24   0   9

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --EAKG--KTRG   L               +4cn3_D    
                               +-2 
  --ECKG--RGRG   L             ! +2nll_B    
                     +---------6 
  ----KGVT--RG   L   !         ! +5cbz_E    
                     !         +-3 
  --ECKA--RGRG   L   !           +4nqa_I    
                   --7 
  ----KGVG--RG   L   !              +4tnt_B    
                     !            +-1 
  --ECKGAG--RG   L   !          +-4 +4ond_A    
                     !          ! ! 
  ----KGVT--RG       +----------5 +5emc_A    
                                ! 
  YGECKGAGKGRG   L              +4oln_B

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updated Fri Sep 13 16:11:01 2024