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legend  pdf

structure nameHLRH-1 DNA BINDING DOMAIN - 12BP OCT4 PROMOTER COMPLEX
(Nuclear receptor subfamily 5 group A member 2)
referenceTuntland et al. 'J. 428 4981 2016
sourceHomo sapiens
experimentX-ray (resolution=2.20, R-factor=0.158)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
redundant complexes2a66
reference complex2a66_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKKRRR

Estimated binding specificities ?

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# IC=7.489 IC/col=0.832 n_of_columns=9 specificity:   
A |   7   9  66  96   0   0  24   7  96
C |   9  73   9   0   0   0  24   7   0
G |   7   7   7   0  96  96  24   7   0
T |  73   7  14   0   0   0  24  75   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECKG--KGRG--RCRC   L   +----------------------2ff0_A    
                           ! 
  CAECKG--KGRG------   L   !                 +----6l6q_B    
                           !         +-------6 
  ----KGVT--RG------     --9         !       +----5emp_A    
                           !         ! 
  --DGKG--RTRG------   L   !         !              +3cbb_A    
                           !         !            +-1 
  --EAKG--RTRTRT----       +---------8         +--2 +4umm_E    
                                     !         !  ! 
  --EAKG--RTRTRT----                 !         !  +2han_B    
                                     !     +---5 
  ----KAVA--RA------   L             !     !   !    +5e69_A    
                                     !     !   !  +-3 
  --ECKG--KGRG------                 +-----7   +--4 +3dzy_A    
                                           !      ! 
  --ETKGAT--RG------   L                   !      +1lat_A    
                                           ! 
  --ECKG--RGRG------   L                   +------3dzy_D

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updated Sat Aug 2 09:12:23 2025