interface graph thumbnail
legend  pdf

structure nameFIVE-FINGER GLI/DNA COMPLEX
(PROTEIN FIVE-FINGER GLI)
referencePavletich et al. Science 261 1701 1993
sourceHomo sapiens
experimentX-ray (resolution=2.60, R-factor=0.228)
structural superfamilyC2H2 and C2HC zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureAYRNASDKRDPSSRK

Estimated binding specificities ?

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# IC=11.553 IC/col=0.825 n_of_columns=14 specificity:   
A |   0  72   0   0  96  89   0   9  62  96  24  24  23  51
C |   0   6  96  96   0   6  96  84   9   0  24  24  52   3
G |  96  15   0   0   0   1   0   0   6   0  24  24  13  36
T |   0   3   0   0   0   0   0   3  19   0  24  24   8   6
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: GLI
CCAATPubMed2gli_A(1.04e-02)
GACCACCCACPubMed2gli_A(1.23e-07)
GACCACCCAPubMed2gli_A(8.56e-09)
TGGGGGGTPubMed2gli_A(1.72e-03)

Dendrogram of similar interfaces ?

matrix format
  
  AT--YC------RA----NC----ATSGDC--KG--DCPTSGSARTKG--   L                      +------2gli_A    
                                                                 +------------3 
  KT--STHT----RG--DAQARGRGSTDCHG--TT--RG--DAEG--RG--   L     +---5            +------6b0o_A    
                                                             !   ! 
  ----------NGKT--WTKG------HTHG--RGTGTT--ACNA--KGRG   L   +-6   +-------------------1tf3_A    
                                                           ! ! 
  ------------RGSTDAHARGRGSTDCHG--TT--RG--DAEG--RG--   L   ! +-----------------------5kl3_A    
                                                           ! 
  ------------QA--TCNA--QAHTTT----QA--TTLAHGTCDTRG--   L --7                         +1g2d_F    
                                                           !                      +--1 
  EC--SCKGRG--LT--FCNA--QA--TTNA--------------------   L   !      +---------------2  +1ubd_C    
                                                           !      !               ! 
  --TCYCKARG--QA----TC--RA--SCDC--VT----------------       +------4               +--5yeg_A    
                                                                  ! 
  ----------RGST--YGYC--QC--TGSTRGYT----------------              +------------------4is1_C    
                                                         

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updated Fri Sep 13 16:18:44 2024