interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX.
(INTERFERON REGULATORY FACTOR 2)
referenceTaniguchi et al. 'EMBO 18 5028 1999
sourceMus musculus
experimentX-ray (resolution=2.20, R-factor=0.202)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes2irf_GH 2irf_IJKL
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHKANRCNS

Estimated binding specificities ?

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# IC=4.007 IC/col=0.801 n_of_columns=5 specificity:   
A |   9   9   0   9  96
C |  11   9   0  11   0
G |  67   9  96   9   0
T |   9  69   0  67   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: IRF-2
GAAAGTPubMed2irf_IJKL(1.04e-03)
GAAAGPubMed2irf_IJKL(7.85e-05)
AAGTGAPubMed2irf_GH(1.03e-02), 2irf_IJKL(1.03e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ECKTRGAT--RGHT--RA   L                               +---4mhg_A    
                             +-------------------------1 
  --KTRG----RGYT----   L   +-2                         +---4bqa_A    
                           ! ! 
  ----NASTRGHT--ST--   L --3 +-----------------------------2uzk_A    
                           ! 
  ----NASTRTHT--ST--   L   +-----------------------------3l2c_A    
                         

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updated Fri Sep 13 16:24:30 2024