2irf_L : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX. (INTERFERON REGULATORY FACTOR 2)
reference	Taniguchi et al. 'EMBO 18 5028 1999
source	Mus musculus
experiment	X-ray (resolution=2.20, R-factor=0.202)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	2irf_GH 2irf_IJKL
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2irf_L interface=36,71,75,76,78,79,82,83, rmrmrpwleeqinsntipglkwlnkekkifqipwmHaarhgwdvekdaplfrnwaihtgkhqpgidkpdpKtwkANfRCamNSlpdieevkdrsikkgnnafrvyrmlp
interface signature	HKANRCNS

Estimated binding specificities ?

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# IC=3.895 IC/col=0.779 n_of_columns=5

specificity:

A |   0  72   0  69   8
C |   0   8  87   8  72
G |   0   8   1  11   8
T |  96   8   8   8   8

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: IRF-2
GAAAGT	PubMed	2irf_IJKL(1.04e-03)
GAAAG	PubMed	2irf_IJKL(7.85e-05)
AAGTGA	PubMed	2irf_GH(1.03e-02), 2irf_IJKL(1.03e-03)

Dendrogram of similar interfaces ?

matrix format

  
  HT----ATNTRGCT----SC   L                          +--------8hcm_A    
                               +--------------------1 
  --DCKTRG----RGYA----   L   +-2                    +--------3zp5_A    
                             ! ! 
  ------NASTRTHTNTSTLT   L --3 +-----------------------------3co6_C    
                             ! 
  --DCKTRGST--RGYC----   L   +-----------------------------4uno_A

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updated Mon Jun 29 15:15:13 2026