2irf_L : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF AN IRF-2/DNA COMPLEX. (INTERFERON REGULATORY FACTOR 2)
reference	Taniguchi et al. 'EMBO 18 5028 1999
source	Mus musculus
experiment	X-ray (resolution=2.20, R-factor=0.202)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Interferon regulatory factor transcription f;
multimeric complexes	2irf_GH 2irf_IJKL
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2irf_L interface=36,71,75,76,78,79,82,83, rmrmrpwleeqinsntipglkwlnkekkifqipwmHaarhgwdvekdaplfrnwaihtgkhqpgidkpdpKtwkANfRCamNSlpdieevkdrsikkgnnafrvyrmlp
interface signature	HKANRCNS

Estimated binding specificities ?

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# IC=3.834 IC/col=0.767 n_of_columns=5

specificity:

A |   0  69   1  69   8
C |   0  11  87   8  72
G |   0   8   0   8   8
T |  96   8   8  11   8

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: IRF-2
GAAAGT	PubMed	2irf_IJKL(1.04e-03)
GAAAG	PubMed	2irf_IJKL(7.85e-05)
AAGTGA	PubMed	2irf_GH(1.03e-02), 2irf_IJKL(1.03e-03)

Dendrogram of similar interfaces ?

matrix format

  
  ECKTRGAT--RGHT--RA   L                               +---4mhg_A    
                             +-------------------------1 
  --KTRG----RGYT----   L   +-2                         +---4bqa_A    
                           ! ! 
  ----NASTRGHT--ST--   L --3 +-----------------------------2uzk_A    
                           ! 
  ----NASTRTHT--ST--   L   +-----------------------------3l2c_A

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updated Sat Jan 10 05:19:39 2026