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structure nameCRYSTAL STRUCTURE OF FOXO1 DBD BOUND TO DBE1 DNA
(Forkhead box protein O1)
referenceMarmorstein et al. Structure 16 1407 2008
sourceHomo sapiens
experimentX-ray (resolution=2.10, R-factor=?)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes4lg0_AB 5dui_AB 6lbi_CD 6lbi_GH 6lbi_KL
redundant complexes3co7_F 5dui_A 6lbi_G 4lg0
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHNSL

Estimated binding specificities ?

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# IC=5.066 IC/col=0.844 n_of_columns=6 specificity:   
A |   6  13   6   0   0  82
C |   6  13   6   0   6   0
G |   6  64   9   0   0  14
T |  78   6  75  96  90   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOXO1
TGAGATGTTTTGAAAGPubMed3co6_C(3.69e-04)
GTAAACAAPubMed3co6_C(3.67e-09), 5dui_A(1.82e-03)
CAAAACAPubMed3co6_C(6.27e-06)
AATAACAPubMed3co6_C(3.38e-03)
ATAAACAPubMed3co6_C(8.33e-10), 5dui_A(1.03e-03)
GTAAACAPubMed3co6_C(8.33e-10), 5dui_A(1.03e-03)
CAAAACAAAACAPubMed3co6_C(1.61e-04)

Dendrogram of similar interfaces ?

matrix format
  
  --------NAST--RTHT--ST--------   L                         +---3l2c_A    
                                                       +-----1 
  --------NAST--RGHT--STLT------   L            +------2     +---7cby_C    
                                                !      ! 
  --RGSTRTSTHG----------------RA   L   +--------3      +---------3zpl_B    
                                       !        ! 
  TT--KATTQTTG----LTRT----KAFT--   L --4        +----------------2p7c_B    
                                       ! 
  ------KT--RGAT--RGNT----------   L   +-------------------------8smh_F

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updated Fri Sep 13 16:57:25 2024