7yzb_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE HUMAN FOXH1 BOUND TO THE TGTGGATT SITE (Forkhead box protein H1)
reference	Macias et al. 'To ? ? 2022
source	Homo sapiens
experiment	X-ray (resolution=1.47, R-factor=0.164)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Fork head domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7yzb_A interface=3,5,54,55,57,58,59,61,79, krYlRhdkppytylamialviqaapsrrlklaqiirqvqavfpffredyegwkDSiRHNlSsnrcfrkvpkdpakpqaKgnfwavdvslipaealrlqntalcrrwqfakdlgpyvlhgrpyrpp
interface signature	YRDSRHNSK

Estimated binding specificities ?

readout + contact

# IC=9.547 IC/col=0.955 n_of_columns=10

specificity:

A |  79  83   0   4   0  83   0  83  79   5
C |   8   4   0  83  96   4  96   4   5   4
G |   4   5   0   4   0   5   0   4   8   4
T |   5   4  96   5   0   4   0   5   4  83

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ----------NAST--RGHT--STLT----   L                            +------7cby_C    
                                                   +------------1 
  ----------NAST--RTHT--ST------   L          +----2            +------3l2c_A    
                                              !    ! 
  TT----KATTQTTG----LTRT----KAFT   L     +----3    +-------------------2p7c_B    
                                         !    ! 
  --------KT--RGAT--RGNT--------   L   +-4    +------------------------8smh_F    
                                       ! ! 
  ----------NC----ICNA--RGRG----   L --5 +-----------------------------4xrm_B    
                                       ! 
  --KTHG------------------------       +-----------------------------5hdn_C

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updated Wed Dec 18 14:50:32 2024