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legend  pdf

structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXH1 BOUND TO THE TGTGGATT SITE
(Forkhead box protein H1)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.47, R-factor=0.164)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYRDSRHNSK

Estimated binding specificities ?

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# IC=9.527 IC/col=0.953 n_of_columns=10 specificity:   
A |  76  84   0   6   0  87   0  84  76   3
C |  11   3   0  84  96   3  96   3   6  14
G |   3   3   0   3   0   3   0   6  11   3
T |   6   6  96   3   0   3   0   3   3  76
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------------------QTNAST--RGHTNT--STLA--------   L             +-----------------------------2hdc_A    
                                                                   +-2 
  ------------------------------NG----RGRG--YC------   L         +-3 +-----------------------------1cf7_B    
                                                                 ! ! 
  --------FG------TTPTRTAT----LT--------------------   L       +-4 +-----------------------------4hqe_A    
                                                               ! ! 
  ----------------------------ST----RTQT------MT----         +-5 +-----------------------------3hts_B    
                                                             ! ! 
  ----------YC------HGSTQT--YTPT--------------------   L   +-6 +-----------------------------5x11_A    
                                                           ! ! 
  LAHAKARA--------------------------------------IAVA     --7 +-----------------------------6dta_A    
                                                           ! 
  ----------------------------RG----RGYA------------   L   !                 +-----------1dux_F    
                                                           +-----------------1 
  ------------KTHG----------------------------------                         +-----------5hdn_C    
                                                         

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updated Wed Dec 20 00:20:56 2023