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legend  pdf

structure nameCRYSTAL STRUCTURE OF THE HUMAN FOXH1 BOUND TO THE TGTGGATT SITE
(Forkhead box protein H1)
referenceMacias et al. 'To ? ? 2022
sourceHomo sapiens
experimentX-ray (resolution=1.47, R-factor=0.164)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYRDSRHNSK

Estimated binding specificities ?

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# IC=9.632 IC/col=0.963 n_of_columns=10 specificity:   
A |  74  82   0   6   0  87   0  84  78   4
C |  14   4   0  82  96   1  96   4   4   4
G |   4   4   0   4   0   8   0   4  10   4
T |   4   6  96   4   0   0   0   4   4  84
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----------NAST--RGHT--STLT----   L                            +------7cby_C    
                                                            +---1 
  ----------NAST--RTHT--ST------   L          +-------------2   +------3l2c_A    
                                              !             ! 
  TT----KATTQTTG----LTRT----KAFT   L     +----3             +----------2p7c_B    
                                         !    ! 
  --------KT--RGAT--RGNT--------   L   +-4    +------------------------8smh_F    
                                       ! ! 
  ----------NC----ICNA--RGRG----   L --5 +-----------------------------4xrm_B    
                                       ! 
  --KTHG------------------------       +-----------------------------5hdn_C    
                                     

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updated Sat Sep 14 07:52:09 2024