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structure nameCRYSTAL STRUCTURE OF ARISTALESS AND CLAWLESS HOMEODOMAINS BOUND TO DNA
(HOMEODOMAIN-CONTAINING PROTEIN)
referenceMiyazono et al. 'Embo 29 1613 2010
sourceDROSOPHILA MELANOGASTER
experimentX-ray (resolution=2.70, R-factor=0.234)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes3a01_AB 3a01_EF
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHRRTQN

Estimated binding specificities ?

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# IC=6.234 IC/col=1.039 n_of_columns=6 specificity:   
A |   0  96  96   0  20  77
C |  96   0   0   0  19   0
G |   0   0   0   0  19  19
T |   0   0   0  96  38   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: clawless
TAATTAAPubMed3a01_E(7.92e-06), 3a01_AB(5.68e-10)

Dendrogram of similar interfaces ?

matrix format
  
  RC--RT--ITQCNAACRG--   L                                   +6a8r_A    
                                               +-------------2 
  --RCRT--NT--NAITRG--                         !             +5zjt_B    
                                             +-4 
  ----RT--VAQTNA------   L                   ! !              +5hod_A    
                                           +-5 +--------------1 
  ----RT--IAQCNAYA--RT   L                 ! !                +1nk2_P    
                                           ! ! 
  --RTRT--IAKGNA------   L            +----6 +---------------6m3d_C    
                                      !    ! 
  ----RTFTYAQTNAATRG--   L            !    !           +----6ryd_F    
                                    +-7    +-----------3 
  ------RTVAITNAMCRG--   L          ! !                +----1yrn_A    
                                +---8 ! 
  ----RA--YAQTNAAARG--   L      !   ! +---------------------6wig_A    
                             +--9   ! 
  ------RCVACTNAQA----   L   !  !   +----------------------7xrc_C    
                           -10  ! 
  ----RARCVTCTNAQTRC--   L   !  +--------------------------1au7_A    
                             !  
  ----RT--VAQTNA------   L   +-----------------------------1fjl_B    
                           

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updated Fri Sep 13 16:52:12 2024