interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF HEPATOCYTE NUCLEAR FACTOR 4ALPHA IN COMPLEX WITH DNA: DIABETES GENE PRODUCT
(Hepatocyte Nuclear Factor 4-alpha, DNA binding domain)
referenceMelikishvili et al.
sourceHomo sapiens
experimentX-ray (resolution=2.00, R-factor=?)
structural superfamilyGlucocorticoid receptor-like DNA-binding domain;
sequence familyZinc finger, C4 type two domains;
multimeric complexes3cbb_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKRR

Estimated binding specificities ?

readout + contactlogo
# IC=4.250 IC/col=0.850 n_of_columns=5 specificity:   
A |  12   0  12  60   0
C |  12   0   0  12  96
G |  12  96  84  12   0
T |  60   0   0  12   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-4
GGGTCAPubMed3cbb_AB(1.68e-03)
TGGACTTAGTTCAPubMed3cbb_A(1.80e-05)
AGTTCAPubMed3cbb_A(3.04e-03), 3cbb_AB(1.75e-04)
CCCTTTGGAPubMed3cbb_A(2.95e-03)
TGAACCCTTGACCPubMed3cbb_AB(3.85e-12)
TGTCCTPubMed3cbb_A(3.71e-04)

Dendrogram of similar interfaces ?

matrix format
  
  CAECKG--KGRG--   L                          +----1cit_A    
                                +-------------4 
  --EAKG--KTRG--   L            !             !    +4umm_A    
                                !             +----1 
  ----KGVG--RG--   L            !                  +4tnt_B    
                         +------5 
  ----KGVT--RG--   L     !      !                  +5emc_A    
                         !      !                +-2 
  --ECKGAGKGRG--   L   +-6      +----------------3 +1hcq_E    
                       ! !                       ! 
  --ECKGAG--KTRG   L   ! !                       +-4aa6_B    
                     --7 ! 
  ----KGVT--RG--   L   ! +-------------------------2c7a_B    
                       ! 
  --ECKGAG--RG--   L   +--------------------------4ond_A

home
updated Mon Jun 29 15:55:58 2026