| structure name | CRYSTAL STRUCTURE OF HEPATOCYTE NUCLEAR FACTOR 4ALPHA IN COMPLEX WITH DNA: DIABETES GENE PRODUCT (Hepatocyte Nuclear Factor 4-alpha, DNA binding domain) |
| reference | Melikishvili et al. |
| source | Homo sapiens |
| experiment | X-ray (resolution=2.00, R-factor=?) |
| structural superfamily | Glucocorticoid receptor-like DNA-binding domain; |
| sequence family | Zinc finger, C4 type two domains; |
| multimeric complexes | 3cbb_AB |
| links to other resources | NAKB  PDIdb DNAproDB |
| protein sequence | |
| interface signature | DKRR |
Estimated binding specificities ?
| readout + contact |  |
A | 0 11 9 0 76 C | 0 9 69 96 9 G | 96 19 9 0 11 T | 0 57 9 0 0scan! |
Related DNA sequences reported in the literature ?
| site | source | matches (E-value) |
|---|---|---|
| term: HNF-4 | ||
| GGGTCA | PubMed | 3cbb_AB(1.68e-03) |
| TGGACTTAGTTCA | PubMed | 3cbb_A(1.80e-05) |
| AGTTCA | PubMed | 3cbb_A(3.04e-03), 3cbb_AB(1.75e-04) |
| CCCTTTGGA | PubMed | 3cbb_A(2.95e-03) |
| TGAACCCTTGACC | PubMed | 3cbb_AB(3.85e-12) |
| TGTCCT | PubMed | 3cbb_A(3.71e-04) |
Dendrogram of similar interfaces ?
matrix format--ECKG--KGRG-- L +--------2ff0_A +-----------6 ----KGVT--RG-- ! +--------5emp_A ! --EAKG--RTRTRT ! +4umm_E --9 +----1 --EAKG--RTRTRT ! +------------5 +2han_B ! ! ! --ECKG--KGRG-- ! ! +----3dzy_A ! ! --DGKG--RTRG-- L +--8 +3cbb_A ! +--2 CAECKG--KGRG-- L ! +-------4 +6l6q_B ! ! ! --ECKG--RGRG-- L +-----7 +---3dzy_D ! ----KAVA--RA-- L ! +5e69_A +----------3 --ETKGAT--RG-- L +1lat_A |
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updated Sun Aug 3 06:46:11 2025