interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF HUMAN BRN-5 TRANSCRIPTION FACTOR IN COMPLEX WITH CORTICOTROPHIN-RELEASING HORMONE GENE PROMOTER
(POU domain, class 6, transcription factor 1)
referencePereira et al. J.Struct.Biol. 167 159 2009
sourceHomo sapiens
experimentX-ray (resolution=2.51, R-factor=0.212)
structural superfamilylambda repressor-like DNA-binding domains;Homeodomain-like;
sequence familyPou domain Nterminal to homeobox domain;
multimeric complexes3d1n_IK 3d1n_MO
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQSQSSRRRVNQ

Estimated binding specificities ?

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# IC=8.622 IC/col=0.862 n_of_columns=10 specificity:   
A |  73   5  90  96  96  24  16  96   0  73
C |   7   5   0   0   0  24   5   0   5   5
G |   5   7   1   0   0  24   5   0   0  11
T |  11  79   5   0   0  24  70   0  91   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RCRT--VTQTNA--RG   L                +8ejp_B    
                                    +-1 
  RARA--IAQTNA----   L   +----------2 +5ego_B    
                         !          ! 
  --RT--NT--NAIARG   L --3          +-1b72_B    
                         ! 
  ----RTNT--NAIARG   L   +------------4cyc_B    
                       

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updated Sat Jan 10 05:48:42 2026